Dopaminergic neurotransmission and status of brain iron

  • M. B. H. Youdim
Part of the Key Topics in Brain Research book series (KEYTOPICS)


The highly characteristic uneven distribution of iron in the human and animal brains, with high iron content present in globus pallidus, substantia nigra, ventral pallidum, caudate nucleus, intra penduncular nuclei, red nucleus and dente gyrus, suggests a functional importance for this metal.Our studies have clearly demonstrated that the homeostasis of brain iron is important for normal functioning of this organ. Either increased or decreased availability of iron in the above specific regions significantly alters the GABA and dopamine neurotransmission.


Iron Deficiency Tyrosine Hydroxylase Caudate Nucleus Brain Iron Dopaminergic Neurotransmission 
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Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • M. B. H. Youdim
    • 1
  1. 1.Department of Pharmacology, Rappaport Family Research InstituteFaculty of Medicine, TechnionHaifaIsrael

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