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Positron emission tomography in Parkinson’s disease glucose metabolism

  • M. Huber
  • K. Herholz
  • V. Holthoff
  • W.-D. Heiss
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

18FDG-PET results in 11 patients with Parkinson’s disease are presented. Reductions in total glucose utilization were noted in three non-demented and two demented patients, in the latter there was also a significant cortical metabolic reduction. In two patients with lateralized tremor increased metabolic rates in the cerebellum and contralateral sensorimotor region were noted. There was no asymmetry of basal ganglia glucose metabolism in patients with lateralized Parkinson’s syndrome. Decline in dopaminergic inhibitory innervation of the striatal nuclei due to neuronal degeneration in some patients leads to increased metabolism in the basal ganglia.

Keywords

Positron Emission Tomography Positron Emission Tomography Study Cereb Blood Flow Demented Patient Lentiform Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • M. Huber
    • 1
  • K. Herholz
    • 1
  • V. Holthoff
    • 1
  • W.-D. Heiss
    • 2
  1. 1.Department of NeurologyUniversity of CologneFederal Republic of Germany
  2. 2.Max-Planck-Institut für neurologische ForschungCologneFederal Republic of Germany

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