Positron emission tomography in Parkinson’s disease glucose metabolism
18FDG-PET results in 11 patients with Parkinson’s disease are presented. Reductions in total glucose utilization were noted in three non-demented and two demented patients, in the latter there was also a significant cortical metabolic reduction. In two patients with lateralized tremor increased metabolic rates in the cerebellum and contralateral sensorimotor region were noted. There was no asymmetry of basal ganglia glucose metabolism in patients with lateralized Parkinson’s syndrome. Decline in dopaminergic inhibitory innervation of the striatal nuclei due to neuronal degeneration in some patients leads to increased metabolism in the basal ganglia.
KeywordsPositron Emission Tomography Positron Emission Tomography Study Cereb Blood Flow Demented Patient Lentiform Nucleus
Unable to display preview. Download preview PDF.
- Heiss WD, Pawlik G, Herholz K, Wagner R, Göldner H, Wienhard K (1984) Regional kinetic constants and cerebral metabolic rate for glucose in normal human volunteers determined by dynamic positron emission tomography of (18F)-2-fluoro-2-deoxy-D-glucose. J Cereb Blood Flow Metab 4: 212–223PubMedCrossRefGoogle Scholar
- Kuhl DE, Metter EJ, Riege WH, Markham CH (1984) Patterns of cerebral glucose utilization in Parkinson’s disease and Huntington’s disease. Ann Neurol 15 [Suppl]: S 119–125Google Scholar
- Kuhl DE, Metter EJ, Benson DF, Ashford JW, Riege WH, Fujikawa DG, Markham CH, Mazziotta JC, Maltese A, Dorsey DA (1985) Similarities of cerebral glucose metabolism in Alzheimer’s and Parkinsonian dementia. J Cereb Blood Flow Metab 5 [Suppl] 1: S 169–170Google Scholar
- Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido P, Casella V, Fowler J, Hoffman E, Alavi A, Som P (18F)-fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137Google Scholar