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Effect of Nimodipine on Mitochondrial Respiration in Different Rat Brain Areas After Subarachnoid Haemorrhage

  • Conference paper
Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 43))

Summary

The mitochondrial respiration was evaluated in three different rat brain areas (cerebral cortex, hippocampus and brain stem) after experimental subarachnoid haemorrhage (SAH). The haemorrhage was induced by injecting 0.35 ml of autologous arterial blood into cisterna magna. Intravenous administration of Nimodipine (2 µg/kg/min for 30 minutes) was started immediately after the haemorrhage induction. At the set time (1 hour after SAH procedure), animals were sacrificed and non-synaptic mitochondria from the above mentioned areas were isolated. The following respiratory parameters were evaluated utilizing glutamate plus malate and succinate plus rotenone as substrates: state 3, state 4, uncoupled state, respiratory control ratio (RCR) and ADP/O ratio. SAH significantly influences respiratory parameters, mainly RCR; the cerebral cortex and brain stem seem to be more sensitive during the acute phase of vasospasm which follows SAH procedure. Nimodipine treatment significantly ameliorates mitochondrial respiratory conditions.

This experimental work was supported in part by a Grant of Regione Lombardia, Milano, Italy, 1985, and by Bayer Italia S.p.A.

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Author information

Authors and Affiliations

  1. Department of Surgery, Neurosurgical Section, Faculty of Medicine, University of Pavia, Italy

    R. Rodriguez y Baena, P. Gaetani M.D., V. Silvani & G. Spanu

  2. Institute of Pharmacology, Faculty of Science, University of Pavia, Italy

    F. Marzatico

Authors
  1. R. Rodriguez y Baena
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  2. P. Gaetani M.D.
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  3. V. Silvani
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  4. G. Spanu
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  5. F. Marzatico
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Editor information

Editors and Affiliations

  1. Servicio de Neurocirugía, Hospital de Bellvitze, University of Barcelona, Barcelona, Spain

    Fabian Isamat

  2. Newport, Dyfed, UK

    Antony Jefferson

  3. Neurochirurgische Universitätsklinik, Homburg/Saar, Federal Republic of Germany

    Friedrich Loew

  4. Department of Neurological Surgery, Institute of Neurology, The National Hospital, London, UK

    Lindsay Symon TD, FRCS

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© 1988 Springer-Verlag

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Rodriguez y Baena, R., Gaetani, P., Silvani, V., Spanu, G., Marzatico, F. (1988). Effect of Nimodipine on Mitochondrial Respiration in Different Rat Brain Areas After Subarachnoid Haemorrhage. In: Isamat, F., Jefferson, A., Loew, F., Symon, L. (eds) Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987. Acta Neurochirurgica, vol 43. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8978-8_38

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  • DOI: https://doi.org/10.1007/978-3-7091-8978-8_38

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8980-1

  • Online ISBN: 978-3-7091-8978-8

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