Summary
Peripheral blood mononuclear cells (PBMC) of malignant gliomabearing patients were stimulated in vitro with a glucomannan-protein antigen of Candida albicans (GMP) or Interleukin-2 (IL-2), then assayed for proliferation and production of Interferon gamma. PBMC of healthy, age and sex matched subjects were the controls. PBMC from glioma-bearing patients did not differ, as a whole, from PBMC of healthy donors in IL-2 or GMP-induced proliferation. However, they showed a definitely lesser ability to produce IFN. The results are discussed in the framework of the impairment of immune responses known to affect alioma-bearing patients.
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References
Ommaya AK (1986) Immunotherapy of gliomas: a review. Adv Neurol 15: 337–354
Terry WD, Rosemberg SA (eds) (1982) Immunotherapy of human cancer. Elsevier, North-Holland, New York
Brooks WH, Caldwell HD, Mortara RH (1974) Immune responses in patients with glioma. Surg Neurol 2: 419–423
Mahaley MS, Brooks WH, Roszman TL, Bigner DD, Dudka L, Richardson S (1977) Immunobiology of primary intracranial tumours. Part I: Studies of cellular and humoral general immune competence of brain-tumour patients. J Neurosurg 46: 467–479
Blomgren H, Blom U, Ullen H (1986) Relation between the site of primary intracranial tumours and mitogenic responses of blood lymphocytes. Cancer Immunol Immunother 21: 31–38
Roszman TL, Brooks WH, Elliot LH (1982) Immunobiology of primary intracranial tumours. VI Suppressor cell function and lectin-binding lymphocyte subpopulations in patients with cerebral tumours. Cancer 50: 1273–1279
Brooks WH, Netsky MG, Normansell DE, Horwitz DA (1972) Depressed cell-mediated immunity in patients with primary intracranial tumours. J Exp Med 136: 1631–1647
Newelt EA, Kikuchi K, Hill S, Lipsky P, Frenkel EP (1985) Immune responses in patients with brain tumours: factors such as anticonvulsants that may contribute to impaired cell-mediated immunity. Cancer 51: 248–255
Ausiello C, Spagnoli GC, Boccanera M, Casalinuovo I, Malavasi F, Casciani CU, Casson A (1986) Proliferation of human peripheral blood mononuclear cells induced by Candida albicans and its cell wall fractions. J Med Microbiol 22: 195–202
Gillis S, Ferm MM, Ou W, Smith KA (1978) T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 120: 2077–2085
Stanton GJ, Langford MJ, Dianzani F (1981) Virus yield reduction assay for IFN by titration of Sindbis virus haemagglutinin. Methods Enzymol 78: 351–357
Ullen H, Blom U, Blomgren H (1986) Natural killer activity of blood lymphocytes in patients with primary intracranial tumours. Correlation of histological tumour type and anatomical site. Eur J Cancer Clin Oncol 10: 1239–1245
Ausiello C, Spagnoli GC, Antonelli G, Malavasi F, Dianzani F, Casciani CU, Cassone A (1987) Generation and characterization of cytotoxic activity against tumour cell lines in human peripheral blood mononuclear cells stimulated in vitro by a glucomannan-protein preparation of Candida albicans. J Biol Reg Homeost Agents 1: 1
Rosemberg S (1985) Lymphokine-activated killer cells: a new approach to immunotherapy of cancer. JNCI 75: 595–603
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© 1988 Springer-Verlag
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Maleci, A., Ausiello, C., Gagliardi, F.M., Guidetti, B., Cassone, A. (1988). The Response of Peripheral Blood Mononuclear Cells of Glioma-Bearing Patients to Stimulation with Microbial Antigen and IL-2: Proliferation and IFN-Gamma Production. In: Isamat, F., Jefferson, A., Loew, F., Symon, L. (eds) Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987. Acta Neurochirurgica, vol 43. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8978-8_28
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DOI: https://doi.org/10.1007/978-3-7091-8978-8_28
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8980-1
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