The Response of Peripheral Blood Mononuclear Cells of Glioma-Bearing Patients to Stimulation with Microbial Antigen and IL-2: Proliferation and IFN-Gamma Production

  • A. Maleci
  • C. Ausiello
  • F. M. Gagliardi
  • B. Guidetti
  • A. Cassone
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 43)


Peripheral blood mononuclear cells (PBMC) of malignant gliomabearing patients were stimulated in vitro with a glucomannan-protein antigen of Candida albicans (GMP) or Interleukin-2 (IL-2), then assayed for proliferation and production of Interferon gamma. PBMC of healthy, age and sex matched subjects were the controls. PBMC from glioma-bearing patients did not differ, as a whole, from PBMC of healthy donors in IL-2 or GMP-induced proliferation. However, they showed a definitely lesser ability to produce IFN. The results are discussed in the framework of the impairment of immune responses known to affect alioma-bearing patients.


Peripheral Blood Mononuclear Cell Candida Albicans Glioma Patient Healthy Subjects9 Brain Stem Glioma 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Maleci
    • 4
  • C. Ausiello
    • 2
  • F. M. Gagliardi
    • 1
  • B. Guidetti
    • 1
  • A. Cassone
    • 3
  1. 1.Dipartimento di Scienze Neurologiche, Sezione di NeurochirurgiaUniversitá di Roma “La Sapienza”RomaItaly
  2. 2.Istituto CNR di Tipizzazione Tissutale e Problemi della DialisiL’AquilaItaly
  3. 3.Istituto Superiore di SanitáLaboratorio di Batteriologia e Micologia MedicaRomaItaly
  4. 4.Dipartimento di Scienze Neurologiche, Sezione di NeurochirurgiaUniversitá di Roma “La Sapienza”RomaItaly

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