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The Response of Peripheral Blood Mononuclear Cells of Glioma-Bearing Patients to Stimulation with Microbial Antigen and IL-2: Proliferation and IFN-Gamma Production

  • A. Maleci
  • C. Ausiello
  • F. M. Gagliardi
  • B. Guidetti
  • A. Cassone
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 43)

Summary

Peripheral blood mononuclear cells (PBMC) of malignant gliomabearing patients were stimulated in vitro with a glucomannan-protein antigen of Candida albicans (GMP) or Interleukin-2 (IL-2), then assayed for proliferation and production of Interferon gamma. PBMC of healthy, age and sex matched subjects were the controls. PBMC from glioma-bearing patients did not differ, as a whole, from PBMC of healthy donors in IL-2 or GMP-induced proliferation. However, they showed a definitely lesser ability to produce IFN. The results are discussed in the framework of the impairment of immune responses known to affect alioma-bearing patients.

Keywords

Peripheral Blood Mononuclear Cell Candida Albicans Glioma Patient Healthy Subjects9 Brain Stem Glioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Maleci
    • 4
  • C. Ausiello
    • 2
  • F. M. Gagliardi
    • 1
  • B. Guidetti
    • 1
  • A. Cassone
    • 3
  1. 1.Dipartimento di Scienze Neurologiche, Sezione di NeurochirurgiaUniversitá di Roma “La Sapienza”RomaItaly
  2. 2.Istituto CNR di Tipizzazione Tissutale e Problemi della DialisiL’AquilaItaly
  3. 3.Istituto Superiore di SanitáLaboratorio di Batteriologia e Micologia MedicaRomaItaly
  4. 4.Dipartimento di Scienze Neurologiche, Sezione di NeurochirurgiaUniversitá di Roma “La Sapienza”RomaItaly

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