Summary
In about one third of patients with violent spasticity due to spinal trauma, multiple sclerosis, and diffuse brain injury adequate control with oral antispastic medication cannot be achieved and successful rehabilitation is severely handicaped. In the past these patients were subjected to destructive chemical procedures or extensive surgery.
The authors present the results of management of uncontrollable spasticity by means of continuous intrathecal administration of baclofen with a totally implantable gas driven pump system (Infusaid). 30 patients were treated between June 1985 and January. 1987. The main indication was incapacitating spasticity resistant to oral treatment with baclofen and caused by spinal cord injury or lesion (11 patients), multiple sclerosis (11 patients), infantile cerebral palsy (3 patients) and cerebral injury, hypoxia or ischaemia (5 patients). Clinical assessment included spasticity scores, integrated electromyography (Iemg) and motography. Effective control for spasticity with mean reduction of Iemg by 55%, decrease of Ashworth’s score from 3 to 0 and improvement of life quality was obtained in all patients with daily dose of 10–800 micrograms of Baclofen. Voluntary resting motoricity was not impaired and there were no untoward central side effects. The excellent effect of intrathecal baclofen in comparison with oral therapy is explained by local, spinal GABAergic inhibitory action of the drug which is delivered directly into spinal subarachnoid space. Dose finding and dose adjustment is performed prior to pump implantation by intermittend injections into a subcutaneous port. The complications of the procedure were minor (catheter displacement, disconnection) and easily correctable. The only limitation of this method is the inability to reduce spasticity in selective muscle groups. Intrathecal long term infusion of Baclofen is an alternative to surgery in treatment of spasticity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bishof W (1951) Die longitudinale Myelotomie. Zbl Neurochir 2: 79–88
Corston RN, Johnson F, Godwin-Austen RB (1981) The assessment of drug treatment of spastic gait. J Neurol Neurosurg Psychiatry 44: 1035–1039
Dralle D, Müller H, Zierski J, Klug N (1985) Intrathecal baclofen for spasticity. Lancet II: 1003
Erickson DL, Blacklock JB, Michaelson MA, Sperling K, Lo JN (1985) Control of spasticity by implantable continuous flow morphine pump. Neurosurgery 16: 215–217
Faigle JW, Keberle H (1972) Metabolismus und Pharmakokinetik von Lioresal. In: Birkmayer W (ed) Aspekte der Muskelspastik. Huber, Bern Stuttgart Wien, pp 94–100
Faigle JW, Keberle H, Degen PH (1981) Pharmakokinetik von Baclofen (Lioresal). In: Bauer HJ, Koella WP, Struppler A (eds) Therapie der Spastik. Verlag für angewandte Wissenschaft, Munich, pp 137–147
Illis S, Read DJ, Sedgwick EM, Tallis RC (1983) Spinal cord stimulation in the United Kingdom. Review. J Neurol Neurosurg Psychiatry 46: 299–304
Jones RF, Burke D, Marosszeky JE, Gillies JD (1970) A new agent for the control of spasticity. J Neurol Neurosurg Psychiatry 33: 464–468
Kasdon DL, Lahti ES (1984) A prospective study of radiofrequency rhizotomy in the treatment of posttraumatic spasticity. Neurosurgery 15: 526–529
Müller H, Gerlach H, Boldt J, Börner U, Hild P, Oehler KU, Zierski J, Hempelmann G (1986) Spastik-Behandlung mit rückenmarksnaher Gabe von Morphin und Midazolam. In vitro-Experimente, Tierversuche und klinische Untersuchungen zur Verträglichkeit und Effektivität. Anaesthesist 35: 306–316
Müller H, Zierski J, Dralle D, Börner U, Hoffmann O (1987) The effect of intrathecal baclofen on electrical muscle activity in spasticity. J Neurol 234: 348–352
Penn RD, Kroin JS (1985) Continuous intrathecal baclofen for severe spasticity. Lancet II: 125–127
Penn RD, Kroin JS (1987) Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 66: 181–185
Schepelmann F (1976) Human motor activity in decerebrate states and their sequelae. Acta Neurochir (Wien) 46: 185–217
Scott BA, Weinstein Z, Chiteman R, Puliam M (1985) Intrathecal phenol and glycerin in metrizamide for treatment of intractable spasms in paraplegia. J Neurosurg 63: 125–127
Müller H, Zierski J, Penn RD (eds) (1988) Local-spinal therapy of spasticity. Springer, Berlin Heidelberg New York Tokyo
Sindou M, Millet MF, Mortamis J, Eysette M (1982) Results of selective posterior rhizotomy in the treatment of painful and spastic paraplegia secondary to multiple sclerosis. Appl Neurophysiol 45: 335–340
Yaksh TL, Müller H (1982) Spinal opiate analgesia. Experimental and clinical studies. Springer, Berlin Heidelberg New York
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag
About this paper
Cite this paper
Zierski, J., Müller, H., Dralle, D., Wurdinger, T. (1988). Implanted Pump Systems for Treatment of Spasticity. In: Isamat, F., Jefferson, A., Loew, F., Symon, L. (eds) Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987. Acta Neurochirurgica, vol 43. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8978-8_21
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8978-8_21
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8980-1
Online ISBN: 978-3-7091-8978-8
eBook Packages: Springer Book Archive