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Further Experiences in the Treatment of Cystic Craniopharyngeomas with Yttrium 90 Silicate Colloid

  • J. Julow
  • F. Lányi
  • M. Hajda
  • G. Szeifert
  • M. Simkovics
  • Sz. Tóth
  • E. Pásztor
Part of the Acta Neurochirurgica Supplementum 42 book series (NEUROCHIRURGICA, volume 42)

Summary

20 patients suffering from cystic craniopharyngioma were treated with intracavitary irradiation on 25 occassions. The beta emitting radionuclide 90Y silicate colloid was instilled into the cyst or cystic part of the tumour. 17patients on 22 occasions underwent followup CT and ophthalmological examinations 1 to 144 (average: 34) months after the intracavitary radioisotope therapy.

An 23 occasions there was an average of 82 to 90% volume decrease of the craniopharyngioma cysts. On two occasions the volume has remained unchanged and the result of the 90Y therapy cannot be evaluated yet.

The neuroophthalmological prognosis was good only when a relatively intact optic disc was seen; when the disc was atrophie the visual deterioration proved to be irreversible.

Pathologically, it is the fibrotic tissue that is responsible for the shrinkage of the cyst.

Keywords

Foreign Body Giant Cell Cyst Volume Cystic Part Intracavitary Irradiation Yttrium Silicate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Backlund EO (1972) Stereotaktik behandling av kranio pharyngeom med intracystiskt Y90 extern Co 60 Besträling. Stockholm: Doktor-thesis.Google Scholar
  2. 2.
    Backlund EO, Axelson B, Noren G, Ribbesjö E, Rähn T, Schnell PO (1984) Stereotactic treatment of craniopharyngeomas. A 15 year material (manuscript).Google Scholar
  3. 3.
    Campbell JB, Hudson FM (1960) Craniobuccal origin, signs and treatment of craniopharyngiomas. Surg Gynec Obstet 111: 183–191.PubMedGoogle Scholar
  4. 4.
    Hajda M, Pásztor E (1981) Prognostical importance of fundus in the improvement of visual functions after the operation of pituitary adenomas. (Hungarian) Szemészet 118: 209–217.Google Scholar
  5. 5.
    Huk WJ, Mahlstedt J (1983) Intracystic radiotherapy (90Y) of craniopharyngiomas: CT-guided stereotaxic implantation of indwelling drainage system. AJNR 4: 803–806.PubMedGoogle Scholar
  6. 6.
    Julow J, Drasny G, Lányi F, Simkovics M, Hajda M, Szeifert G, Tóth Sz, Pásztor E (1987) Use of microcomputer in the treatment of cystic craniopharingeomas with 90Y silicate colloid intracavitary irradiation. (Hungarian) Ideggyógy Szemle 40: 547–552.Google Scholar
  7. 7.
    Julow J, Lányi F, Hajda M, Simkovics M, Arany I, Tóth Sz, Pásztor E (1985) The radiotherapy of cystic craniopharyngioma with intracystic installation of 90Y silicate colloid. Acta Neurochir (Wien) 74: 94–99.CrossRefGoogle Scholar
  8. 8.
    Kodama T, Matsukado Y, Uemura S (1981) Intracapsular irradiation therapy of craniopharyngiomas with radioactive gold. Neurol Med Chir (Tokyo) 21: 39–58.CrossRefGoogle Scholar
  9. 9.
    Lunsford LD, Gumerman L, Levine G(1985) Stereotactic intracavitary irradiation of cystic neoplasms of the brain. ApplNeurophysiol 48: 146–150.Google Scholar
  10. 10.
    Musoline A, Munari C, Blond S, Betti O, Lajat Y, Schaub C, Askienázy S, Chodkiewicz JP (1985) Traitementstereotaxique des kystes expansifs de cranio-pharyngiomas par irradiation endocavitaire beta. Neurochirurgie 31: 169–178.Google Scholar
  11. 11.
    Netzeband G, Sturm V, Georgi P, Sinn H, Schnabel K, Schlegel W, Schabbert S, Marin-Grez M, Gahbauer M (1984) Results of stereotactic intracavitary irradiation of cystic craniophar yngiomas comparison of the effects of Yttrium-90 and Rhenium-186. Acta Neurochir (Wien) [Suppl] 33: 341–344.Google Scholar
  12. 12.
    Schaub C, Bluet-Pajot MT, Videau-Lornet C, Askienazy S, Szikla G (1979) Endocavitary beta irradiation of glioma cysts with colloidal Rhenium 186. In: Szikla G (ed) Stereotactic cerebral irradiation. North Holland, Amsterdam, pp 293–302.Google Scholar
  13. 13.
    Strauss L, Sturm V, Georgi P, Ostertag H, Clorius FH, van Kaick G (1985) Radioisotope therapy of cystic craniopharyngeomas. Int J Radiat Oncol Biol Phys 8: 1581–1585.CrossRefGoogle Scholar
  14. 14.
    Szeifert G, Julow J, Slowik F, Bálint K, Lányi F, Pásztor E (1987) Pathological changes in cystic craniopharyngiomas following intracavital Yttrium-90 treatment. (Hungarian) Magyar Onkológia, 31: 223–229.Google Scholar
  15. 15.
    Szikla G, Musolino A, Miyahara S, Schaub C, Askienázy S (1984) Colloidal Rhenium-186 in endocavitary beta irradiation of cystic craniopharyngiomas and active glioma cysts. Long term results, side effects and clinical dosimetry. Acta Neurochir (Wien) [Suppl] 33: 331–339.Google Scholar
  16. 16.
    Wycis HT, Robbins R, Spiegel-Adolf M, Mészáros J, Spiegel EA (1954) Treatment of a cystic craniopharyngioma by injection of radioactive P 32. Confin Neurol 14: 193–202.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • J. Julow
    • 1
  • F. Lányi
    • 1
  • M. Hajda
    • 1
  • G. Szeifert
    • 1
  • M. Simkovics
    • 1
  • Sz. Tóth
    • 1
  • E. Pásztor
    • 1
  1. 1.National Institute of NeurosurgeryBudapestHungary

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