Summary
Dopaminergic agents including both levodopa and direct-acting agonists induce a variety psychiatric side-effects of which psychosis is the most significant. When this occurs early in the course of treatment, there is usually a history of prior psychotic illness. Chronic treatment can, however, elicit psychosis in individuals without such a history. The possible pathogenesis of this is reviewed.
This work is supported in part by grants from United Parkinson Foundation, Chicago, Illinois, and the Boothroyd Foundation, Chicago, Illinois.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Beasley B, Nutt J, Chase T (1980) Treatment with tryptophan of levodopa associated psychiatric disturbances. Arch Neurol 37: 155–156
Birkmayer W, Danielczyk W, Neumayer E, Riederer P (1974) Nucleus ruber and L-dopa psychosis: biochemical and post-mortem findings. J Neural Transm 35: 93–116
Birkmayer W, Riederer P (1975) Responsibility of extrastriatal areas for the appearance of psychotic symptoms. J Neural Transm 35: 175–182
Coleman M (1971) Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down’s syndrome. Neurology 21: 911–919
Coleman RM, Pollak C, Weitzman E (1980) Periodic movements in sleep (nocturnal myoclonus): relation to sleep disorders. Ann Neurol 8: 416–421
Klawans HL, Goetz C, Bergen D (1975) Levodopa-induced myoclonus. Arch Neurol 32: 331–334
Miller E, Nieburg H (1974) L-tryptophan in the treatment of levodopa-induced psychiatric disorders. Dis Nerv Syst 35: 20–23
Moskovitz C, Moses H, Klawans HL (1978) Levodopa-induced psychosis: a kindling phenomenon. Am J Psych 135: 669–675
Nausieda PA, Weiner WJ, Kaplan LR, Weber S, Klawans HL (1982) Sleep disruption in the course of chronic levodopa therapy: an early feature of levodopa psychosis. Clin Neuropharmacol 5: 183–194
Sharf B, Moskovitz C, Lupton M, Klawans HL (1978) Dream phenomena induced by chronic levodopa therapy. J Neural Transm 43: 143–151
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag
About this paper
Cite this paper
Klawans, H.L. (1988). Psychiatric side effects during the treatment of Parkinson’s disease. In: Obeso, J.A., Horowski, R., Marsden, C.D. (eds) Continuous Dopaminergic Stimulation in Parkinson’s Disease. Journal of Neural Transmission, vol 27. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8954-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8954-2_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82034-6
Online ISBN: 978-3-7091-8954-2
eBook Packages: Springer Book Archive