Eosinophilic granuloma of bone: direct steroid injection

  • S. Wallace
  • C. H. Carrasco
  • C. Charnsangavej
  • M. Cohen


Eosinophilic granuloma of bone is a benign condition that was described as a distinct clinical and pathological entity by Lichtenstein and Jaffe [1] and Otani and Ehrlich [2] in 1940. One year later, Farber suggested a pathological gradation including eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease [3]. In 1953, Lichtenstein consolidated these three entities under the term “histiocytosis X”, thereby emphasizing the inflammatory proliferative reaction common to all three forms of the disease as well as their indefinite etiologies [4]. Eosinophilic granuloma is generally accepted to represent the benign localized form of the disease, while Hand-Schuller-Christian and Letterer-Siwe diseases are thought to be disseminated types; however, the validity of this unifying concept is controversial and other authors stress their individual nature inspite of certain histological similarities [5, 6, 7].


Bone Cyst Eosinophilic Granuloma Percutaneous Needle Biopsy Intralesional Injection Line Membrane 
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Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • S. Wallace
    • 1
  • C. H. Carrasco
    • 1
  • C. Charnsangavej
    • 1
  • M. Cohen
    • 1
  1. 1.Department of Diagnostic RadiologyThe University of Texas System Cancer Center M. D. Anderson Hospital and Tumor InstituteHoustonUSA

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