Summary
Subarachnoid haemorrhage caused by aneurysmal rupture constitutes a great impact on the brain and on the intracranial content as a whole, with emphasis on the subarachnoid spaces and arteries. The rupture is followed by a wide range of pathological alterations in the neural function and an outcome varying from neglected signs subsiding in a few days to immediate death. Two main factors seem to influence the different events after subarachnoid bleeding. One is the rupture itself which can be extremely variable in severity and in its immediate as well as late consequences. The other is the ability of all parts of the intracranial content to recover. In order to understand either of both the other should also be looked at and both have to be dealt with if we are to treat patients with an aneurysmal rupture properly. For this reason a grading of rupture will be given in respect of some characteristic events in the light of neural restoration. Clearing of CSF, resolution of brain oedema, restoration of impaired CBF, absorption of cisternal and parenchymal haematoma are all of importance. The majority of lesions which developed after the rupture are not fatal or irreversible and even the neural tissue destroyed by the impact or late ischaemia can be functionally replaced. Possible methods of treatment for attaining this functional restoration will be discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Becker DP, Young HF, Vries JK et al (1975) Monitoring in patients with brain tumours. Clin Neurosurg 22: 364–388.
Black P, Markowitz RS, Cianci SN (1975) Recovery of motor function after lesions in motor cortex of monkey, in: Outcome of severe damage to the central nervous system, CIBA Foundation Symposium 34. Elsevier, Amsterdam, pp 65–83.
Branston NM, Symon L, Crockard HA (1976) Recovery of the cortical evoked response following temporary middle cerebral artery occlusion in baboons: Relation to local blood flow and PO2. Stroke 7: 151–157.
Burke AM, Younkin D, Gordon J etal (1986) Changes in cerebral blood flow and recovery from acute stroke. Stroke 17: 173–178.
Cowley AR (1983) Influence of fiber tracts on the CT appearance of cerebral edema: anatomic-pathologic correlation. Am J Neurorad 11: 915–925.
Dóczi T (1985) The pathogenetic and prognostic significance of blood-brain barrier damage in the acute stage of aneurysmal subarachnoid haemorrhage. Clincal and experimental studies. Acta Neurochir (Wien) 77: 110–132.
Drake CG (1981) Management of cerebral aneurysm. Stroke 12: 273–283.
Drayer BD, Rosenbaum A (1979) Brain edema defined by cranial computed tomography. J Comput Assist Tomogr 3: 315–323.
Ellington E, Margolis G (1969) Block of arachnoid villus by subarachnoid haemorrhage. J Neurosurg 30: 651–657.
Fedina L, Pásztor E, Kocsis B et al (1986) Activity of peripheral sympathetic efferent nerves in experimental subarachnoid haemorrhage. Part II: Observations during the “early vasospasm” period. Acta Neurochir (Wien) 80: 42–46.
Finn SS, Stephensen SA, Miller CA et al (1986) Observations on the perioperative management of aneurysmal subarachnoid haemorrhage. J Neurosurg 65: 48–62.
Gillingham FJ (1967) The management of ruptured intracranial aneurysms. Scott Med J 12: 377–383.
Grotta JC, Pettigrew LC, Allen S et al (1985) Baseline haemodynamic state and response to hemodilution in patients with acute cerebral ischemia. Stroke 16: 790–795.
Hargadine JR, Branston NM, Symon L (1980) Central conduction time in primate brain ischaemia—a study in baboons. Stroke 11: 637–643.
Hatashita S, Hoff JT, Ishii S (1986) Focal brain edema associated with acute arterial hypertension. J Neurosurg 64: 643–649.
Hossmann KA, Kleihues P (1973) Reversibility of ischemic brain damage. Arch Neurol 29: 375–384.
Hossmann KA, Ophoff BG (1986) Recovery of monkey brain after prolonged ischemia. I. Electrophysiology and brain electrolytes. J Cereb Blood Flow Metab 6: 15–21.
Hossmann KA, Ophoff BG (1986) Recovery of monkey brain after prolonged ischemia. II. Protein synthesis and morphological alterations. J Cereb Blood Flow Metab 6: 22–23.
Jafar JJ, Johns LM, Mullan SF (1986) The effect of mannitol on cerebral blood flow. J Neurosurg 64: 754–759.
Joó F, Rakonczay Z, Wollemann M (1975) cAMP-mediated regulation of the permeability in the brain capillaries. Experimentia 31: 582–583.
Julow J (1979) Prevention of subarachnoid fibrosis after subarachnoid haemorrhage, with urokinase. Acta Neurochir (Wien) 51: 53–61.
Kassell NF, Drake CG (1982) Timing of aneurysm surgery. Neurosurgery 10: 514–519.
Kassell NF, Peerless SJ, Drake CG et al (1980) Treatment of ischemic deficits from cerebral vasospasm with high dose barbiturate therapy. Neurosurgery 7: 593–597.
Kato H, Kogure K, Ohtomo H et al (1985) Correlations between proton nuclear magnetic resonance imaging and retrospective histochemical images in experimental cerebral infraction. J Cereb Blood Flow Metab 5: 267–274.
Klatzo J (1967) Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26: 1–14.
Marion DW, Segal R, Thompson ME (1986) Subarachnoid haemorrhage and the heart. Neurosurgery 18: 101–106.
McQueen JD, Northrup BE, Leibrock LG (1974) Arachnoid clearance of red blood cells. J Neurol Neurosurg Psychiat 37: 1316–1321.
Meyer FB, Anderson RE, Yaksh TL et al (1986) Effect of nimodipine on intracellular brain pH, cortical blood flow, and EEG in experimental focal cerebral ischemia. J Neurosurg 64: 617–626.
Michenfelder JD (1984) Cerebral preservation for intraoperative focal ischemia. Clin Neurosurg 32: 105–113.
Millican CH (1955) Evaluation of carbon dioxide inhalation for acute focal cerebral infraction. Arch Neurol 73: 324–328.
Mizukami M, Takemae T, Kin H et al (1978) Computed tomography of ruptured intracranial aneurysm in acute stage—relationship between vasospasm and high density on CT scan. Brain and Nerve 30: 861–866.
Mohr G, Ferguson G, Kahn M et al (1983) Intraventricular haemorrhage from ruptured aneurysm. J Neurosurg 58: 482–487.
Muizelaar JP, Becker DP (1986) Induced hypertension for the treatment of cerebral ischemia after subarachnoid haemorrhage. Direct effect on cerebral blood flow. Surg Neurol 25: 317–325.
Nagy Z, Mathieson G, Hüttner J (1979) Blood-brain barrier opening to horseradish peroxidase in acute arterial hypertension. Acta Neuropathol 48: 45–53.
Naruse S, Horikawa Y, Tanaka C et al (1984) Measurements of in vivo energy metabolism in experimental cerebral ischemia using 31P-NMR for the evaluation of protective effects of perfluorochemicals and glycerol. Neurol Res 6: 169–175.
Nornes H, Magnaes B (1972) Intracranial pressure in patients with ruptured saccular aneurysm. J Neurosurg 36: 537–547.
Ohta T, Kikuchi H, Hashi K et al (1986) Nizofenone administration in the acute stage following subarachnoid haemorrhage. J Neurosurg 64: 420–426.
Okawara SH (1973) Warning signs prior to rupture of an intracranial aneurysm. J Neurosurg 38: 575–580.
Pásztor E, Fedina L, Kocsis B et al (1986) Activity of peripheral sympathetic efferent nerves in experimental subarachnoid haemorrhage. Part I: Observations at the time of intracranial hypertension. Acta Neurochir (Wien) 79: 125–131.
Post KD, Flamm ES, Goodgold A et al (1977) Ruptured intracranial aneurysms. Case morbidity and mortality. J Neurosurg 46: 290–295.
Rosenstein J, Wang AD, Symon L et al (1985) Relationship between hemispheral CBF, CCT and clinical grade in aneurysmal subarachnoid haemorrhage. J Neurosurg 62: 25–30.
Sano K, Saito I (1978) Timing and indication of surgery for ruptured intracranial aneurysms with regard to cerebral vasospasm. Acta Neurochir (Wien) 41: 49–60.
Spetzler RF, Selman WR, Weinstein P et al (1980) Chronic reversible ischemia: evaluation of a new baboon model. Neurosurgery 7: 257–261.
Standefer M, Little JR (1986) Improved neurological outcome in experimental focal cerebral ischemia treated with propanolol. Neurosurgery 18: 136–140.
Sundt TM Jr, Sharbrough FW, Piepgras DG (1981) Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy. Mayo Clin Proc 56: 533–543.
Suzuki J, Onuma T, Yoshimoto T (1979) Results of early operations on cerebral aneurysms. Surg Neurol 11: 407–412.
Suzuki J, Yoshimoto T (1979) The effect of mannitol in prolongation of permissible occlusion time of cerebral arteries: Clinical data of aneurysm surgery. In: Suzuki J (ed) Cerebral aneurysms. Neuron Publishing Co, Tokyo, pp 330–337.
Symon L (1985) Thresholds of ischaemic applied to aneurysm surgery. Acta Neurochir (Wien) 77: 1–7.
Symon L, Crockard HA, Dorsch NWC et al (1975) Local cerebral blood flow and vascular reactivity in a chronic stable in baboons. Stroke 6: 482–492.
Terada T, Komai N, Hayashi S et al (1986) Haemorrhagic infarction after vasospasm due to ruptured cerebral aneurysm. Neurosurgery 18: 415–418.
Tourtellotte WW, Metz LN, de Yong RN (1964) Spontaneous subarachnoid haemorrhage. Neurology 14: 301–309.
Trojaborg W, Boysen G (1973) Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy. Electroencephal Clin Neurophys 34: 61–69.
Van der Werf AJM (1986) Spasme vasculaire et ischémie cérébrale après hémorragie par rupture anévrysmale. Neurochirurgie 32: 1–22.
Waga S, Ohtsuto K, Handa H (1975) Warning signs in intracranial aneurysms. Surg Neurol 3: 15–20.
Weinstein PR, Anderson GG, Telles DA (1986) Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats. Stroke 17: 318–324.
Wheelock B, Weir B, Watts R et al (1983) Timing of surgery for intracerebral hematomas due to aneurysm rupture. J Neurosurg 58: 476–481.
Wilkins RH (1986) Attempts at prevention or treatment of intracranial arterial spasm: an update. Neurosurgery 18: 808–822.
Yoshimoto T, Uchida K, Kaneko U et al (1979) An analysis of follow-up results of 1000 intracranial saccular aneurysms with definitive surgical treatment. J Neurosurg 50: 152–157.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag/Wien
About this paper
Cite this paper
Pásztor, E., Vajda, J. (1987). Plasticity of the Brain in Respect of Functional Restoration After Subarachnoid Haemorrhage. In: Sano, K., Ishii, S. (eds) Plasticity of the Central Nervous System. Acta Neurochirurgica Supplementum, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8945-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8945-0_5
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8947-4
Online ISBN: 978-3-7091-8945-0
eBook Packages: Springer Book Archive