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Glycosylated Haemoglobins and Neonatal Macrosomia

  • P. Czekelius
  • J. Rollmann

Abstract

The coupling of glucose to haemoglobin is dependent on time, concentration and pH. The optimum pH is 7.4 (Niederau etal., 1980). The process is not catalyzed enzymatically and is relatively slow. Although aldimine is formed by attachment of the sugar to the N-terminal β-chain of haemoglobin, glucose can be split off again by an increase in blood acidity or, for example, by processes occurring during dialysis (Niederau etal., 1980). A stable ketoamine is only formed by a prolonged process of molecular transformation according to Amadori (Fig. 26).

Keywords

Gestational Diabetes Total Haemoglobin Maternal Weight Gain Fetal Macrosomia Maternal Hyperglycaemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • P. Czekelius
    • 1
  • J. Rollmann
    • 1
  1. 1.Centre of Gynaecology and Obstetrics of the Philipps University of MarburgFederal Republic of Germany

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