Glycosylated Haemoglobins and Neonatal Macrosomia
The coupling of glucose to haemoglobin is dependent on time, concentration and pH. The optimum pH is 7.4 (Niederau etal., 1980). The process is not catalyzed enzymatically and is relatively slow. Although aldimine is formed by attachment of the sugar to the N-terminal β-chain of haemoglobin, glucose can be split off again by an increase in blood acidity or, for example, by processes occurring during dialysis (Niederau etal., 1980). A stable ketoamine is only formed by a prolonged process of molecular transformation according to Amadori (Fig. 26).
KeywordsGestational Diabetes Total Haemoglobin Maternal Weight Gain Fetal Macrosomia Maternal Hyperglycaemia
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