The Human Placenta in Gestational Diabetes
The placenta is a complex and so far poorly understood organ which plays the central metabolic role in pregnancy. In addition to synthesizing various hormones it regulates the transport of maternal fuels to the fetus and facilitates maternal metabolic adaptations to different stages of pregnancy (Munro etal., 1983). The placenta of the diabetic woman has attracted much interest largely because it is thought that placental damage may be partially responsible for the unduly high incidence of fetal complications that occur in pregnancies complicated by diabetes mellitus (Persson etal., 1978). The overwhelming number of reports involve structural analysis by light and electron microscopy as excellently reviewed by Fox (1978). Furthermore, for obvious reasons, biochemical studies have focused on alterations in placental carbohydrate metabolism, mainly glycogen content.
KeywordsGestational Diabetes Fetal Growth Glycogen Content Human Placenta Diabetic Mother
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