The Impact of Diet-induced Ketosis During Pregnancy on the Offspring
During pregnancy there is an increased maternal tendency towards ketogenesis. The ke-togenic effect can become even stronger when, in addition to this pregnancy-related influence on energy metabolism, maternal diabetes—Type I, Type II or Gestational Diabetes—is present. Similar metabolic effects are also to be expected with a ketogenic weight reduction diet during pregnancy. The ketosis of the mother also influences fetal metabolism, since maternal ketone bodies reach the fetus transplacentally. Two groups of investigators (Churchill etal., 1969; Naeye and Chez, 1981) have described the association between long-term elevated in-trauterine ketone body exposition and retarded intellectual development of such children.
KeywordsKetone Body Fetal Brain Maternal Blood Ketogenic Diet Diabetic Mother
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