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The catalytic behaviour of monoamine oxidase

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Monoamine Oxidase Enzymes

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 23))

Summary

Evidence concerning the kinetic mechanism of the reaction catalyzed by monoamine oxidase is reviewed with particular reference to the possibility that the double-displacement mechanism followed by other substrates is not operative with benzylamine. The requirement for only one of the two products of the first half-reaction to be released in a double-displacement mechanism indicates that the available evidence does not exclude such a mechanism with benzylamine as the substrate.

Cases in which substrates also act as time-dependent inhibitors are considered. The mechanism that can describe the inhibition and product formation is similar for the compounds MD 780236 and MPTP whereas that describing the effects of high concentrations of 2-phenethylamine is best described by a scheme involving inhibition occuring via an abortive complex.

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Author information

Author notes

  1. Anne-Marie O’Carroll

    Present address: Laboratory of Clinical Sciences, NIMH, Bethesda, 20205, MD, USA

Authors and Affiliations

  1. Department of Biochemistry, Trinity College, Dublin, Ireland

    Dr. K. F. Tipton, Anne-Marie O’Carroll & J. M. McCrodden

Authors
  1. Dr. K. F. Tipton
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  2. Anne-Marie O’Carroll
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  3. J. M. McCrodden
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Editor information

Editors and Affiliations

  1. Department of Biochemical Pharmacology, University of Uppsala, Sweden

    Lars Oreland

  2. Department of Pharmacology, University of Cambridge, Great Britain

    Brian A. Callingham

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© 1987 Springer-Verlag/Wien

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Tipton, K.F., O’Carroll, AM., McCrodden, J.M. (1987). The catalytic behaviour of monoamine oxidase. In: Oreland, L., Callingham, B.A. (eds) Monoamine Oxidase Enzymes. Journal of Neural Transmission, vol 23. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8901-6_2

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  • DOI: https://doi.org/10.1007/978-3-7091-8901-6_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-81985-2

  • Online ISBN: 978-3-7091-8901-6

  • eBook Packages: Springer Book Archive

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