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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products pp 123–168Cite as

Cyclosporine and Analogues — Isolation and Synthesis — Mechanism of Action and Structural Requirements for Pharmacological Activity

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Abstract

Cyclosporine (1), originally named “Cyclosporin A” (for nomenclature see section 1.2), is the main component of a new family of cyclic peptides each comprising 11 amino acids. These peptides are produced as secondary fungal metabolites by Cylindrocarpon lucidum Booth and Tolypocladium inflatum Gams. Both strains of fungi imperfecti were isolated from soil samples collected in Wisconsin (USA) and Hardanger Vidda (Norway). The isolation, the culture conditions and the taxonomy of these fungi are reported by Dreyfuss et al. (1).

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Authors and Affiliations

  1. Preclinical Research, Sandoz Ltd., Basel, Switzerland

    R. M. Wenger

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Editors and Affiliations

  1. Department of Chemistry, The Florida State University, Tallahassee, Florida, USA

    W. Herz (Professor of Chemistry) (Professor of Chemistry)

  2. Biologisches Institut II, Lehrstuhl für Biochemie der Pflanzen, Albert-Ludwigs-Universität, Freiburg i. Br., Federal Republic of Germany

    H. Grisebach

  3. Chemistry Department, The University, Glasgow, Scotland

    G. W. Kirby Sc. D. (Regius Professor of Chemistry) (Regius Professor of Chemistry)

  4. Institut für Organische Chemie, Universität Basel, Basel, Switzerland

    Ch. Tamm

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Wenger, R.M. (1986). Cyclosporine and Analogues — Isolation and Synthesis — Mechanism of Action and Structural Requirements for Pharmacological Activity. In: Herz, W., Grisebach, H., Kirby, G.W., Tamm, C. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 50. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8888-0_4

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