The Development of New Brain Protective Agents

  • Jiro Suzuki


The brain is known to be particularly susceptible to the effects of ischemia and, once brain tissue has fallen into a state of necrosis due to ischemia, no form of therapy has yet been found to be effective. In recent years, various surgical techniques, such as by-pass surgery and embolectomy, have been developed to treat the ischemic brain, but regardless of how quickly such revascularization methods are employed, in the vast majority of cases a considerable period of time will have elapsed from onset until the completion of revascularization. Not only is it common for the ischemic focus to become infarctic during that period, but when recirculation is achieved in the acute period it is not infrequently the case that brain swelling or hemorrhagic infarction ensues and the patient’s condition actually becomes aggravated18, 32, 117. In light of these facts, we have experimentally investigated—from the clinical neurosurgeon’s perspective—the possibility of developing pharamcological means for preventing the irreversible changes in brain tissue in the brief period between onset and surgical treatment.


Cerebral Blood Flow Cerebral Ischemia Ischemic Brain Evans Blue Ischemic Focus 
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Copyright information

© Springer-Verlag/Wien 1987

Authors and Affiliations

  • Jiro Suzuki
    • 1
  1. 1.Division of Neurosurgery, Institute for Brain DiseasesTohoku University School of MedicineNagamachi, SendaiJapan

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