Abstract
Detailed research on the histopathological changes due to cerebral ischemia date from the work of Spielmeyer58 in the early part of this century. In 1920 he reported that, following cerebral ischemia, there is shrinkage of neurons, in which the cytoplasm becomes acidophilic and the nucleus basophilic and the Nissl bodies disappear. Spielmeyer called such changes “ischemic cell changes”.
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References
Ames A, Wright RL, Kowada M et al (l968) Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52: 437–453
Arsenio-Nunes ML, Hossmann KA, Farkas-Bargeton E (1973) Ultrastructural and histochemical investigation of the cerebral cortex of cat during and after complete ischemia. Acta Nopathol (Berl) 26: 329–344
Brown AW, Brierley JB (1966) Evidence for early anoxic-ischemic cell damage in the rat brain, Experientia (Basel) 22: 546–547
Brown AW, Brierley JB (1968) The nature, distribution and earliest stages of anoxic-ischemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol 49: 87–106
Brown AW, Brierley JB (1972) Anoxic-ischemic cell change in the rat brain. Light microscopic and fine structural observations. J Neurol Sci 16: 59–84
Brown AW, Brierley JB (1973) The earliest alterations in rat neurons and astrocytes after anoxia-ischemia. Acta Neuropathol (Berl) 23: 9–22
Brown AW (1977) Structural abnormalities in neurons. J Clin Pathol [Suppl] 11: 155–169
Calhoun CL, Mottaz JH (1966) Capillary bed of rat cerebral cortex. The fine structure in experimental cerebral infarction. Arch Neurol (Chicago) 15: 320–328
Cammermeyer J (1961) The importance of avoiding dark neurons in the experimental neuropathology. Acta Neuropathol 1: 245–270
Cammermeyer J (1973) Ischemic neuronal disease of Spielmeyer. A reevaluation. Arch Neurol 29: 390–393
Dodson RF, Kawamura Y, Aoyagi M et al (1973) A comparative evaluation of the ultrastructural changes following induced cerebral infarction in the squirrel monkey and baboon. Cytobios 8: 175–182
Fernand DA, Lau JK (1978) An electron microscope study of the effects of acute ischemia in the brain. Acta Anat (Basel) 100: 241–249
Fischer EG, Ames A III, Hedley-Whyte ET et al (1977) Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the “no-reflow phenomenon“. Stroke 8: 36–39
Furlow TW, Martin FM, Harrison LE (1984) Simultaneous measurement of local glucose utilization and blood flow in the rat brain. An autoradiographic method using two tracers labelled with carbon-14. J Cereb Blood Flow Metab 3: 62–66
Garcia JH, Kamijyo Y (1974) Cerebral infarction. Evaluation of histopathological changes after occlusion of a middle cerebral artery in primates. J Neuropath Exp Neurol 33: 408–421
Garcia JH, Trump BF (1975) Cerebral ischemia. The early structural changes and correlation of dynamic abnormalities. In: Whisnant J, Sandok BA (eds) Ninth Conference. Cerebral vascular disease. Grune and Stratton, New York, pp 313–323
Garcia JH, Lossinsky AS, Kauffman FC et al (1978) Neuronal ischemic injury: light microscopy, ultrastructure and biochemistry. Acta Neuropathol (Berl) 43: 85–95
Gildea EF, Cobb S (1930) Effects of anemia on the cerebral cortex of cat. Arch Neurol Psychiat 23: 876–903
Hills CP (1964) Ultrastructural changes in the capillary bed of the rat cerebral cortex in anoxic ischemic brain lesions. Am J Pathol 44: 531–551
Hossmann KA, Sato K (1975) Recovery oi neuronal function after prolonged cerebral ischemia. Science 168: 375–376
Hossmann KA, Kleihues P (1973) Reversibility of ischemic brain damage. Arch Neurol 29: 375–384
Hounthoff KJ, Go KG (1980) Endogenous versus exogenous protein tracer passage in blood-brain barrier damage. In: Cervos-Navarro J, Ferszt R (eds) Brain edema. Adv Neurology 28. Raven Press, New York, pp 78–81
Ito U, Spatz M, Walker JT Jr et al (1975) Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations. Acta Neuropathol (Berl) 32: 209–223
Jenkins LW, Povlishock JT, Becker DP et al (1979) Complete cerebral ischemia. An ul-trastructural study. Acta Neuropathol (Berl) 48: 113–125
Johansen FF, Jorgensen MB, Diemer N (1983) Resistance of hippocampal CA-1 in-terneurons to 20 min of transient cerebral ischemia in the rat. Acta Neuropathol 61: 135–140
Kalimo H, Garcia JH, Kamijyo Y et al (1977) The ultrastructure of „brain death“. II. Electron microscopy of feline cortex after complete ischemia. Virchows Archiv (Cell Pathol) 25: 207–220
Kalimo R, ehncrona S, Soderfeldt B et al (1981) Brain lactic acidosis and ischemic cell damage: 2. Histopathology. J Cereb Blood Flow Metab 1: 313–327
Kirino T, Sano K (1980) Changes in the contralateral dentate gyrus in Mongolian gerbils subjected to unilateral cerebral ischemia. Acta Neuropathol (Berl) 50: 121–129
Kirino T (1980) Degeneration and repair of the brain after cerebral infarction-Changes in the neuropil of the contralateral hemisphere in Mongolian Gerbils. No To Shinkei 32: 1071–1079
Kirino T, Sano K (1984) Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocamps. Acta Neuropathol (Berl) 62: 209–218
Koshu K, Yoshimoto T, Suzuki J (1980) Experimental study on hemorrhagic infarction following recirculation in thalamic ischemic lesion. Neurol Med Chir (Tokyo) 20: 935–938
Kowada M, Ames A III, Majno G et al (1968) Cerebral ischemia. I. An improved experimental method for study; cardiovascular effects and demonstration of an early vascular lesion in the rabbit. J Neurosurg 28: 150–157
Lear JL, Jones SC, Greenberg JH et al (1981) Use of 123I and 14C in a double radionuclide autoradiographic technique for simultaneous measurement of LCBF and LCMR gl. Stroke 12: 589–597
Levine S, Payan H (1966) Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones un-guiculatus). Exp Neurol 16: 255–262
Levine S (1960) Anoxic-ischemic encephalopathy in rats. Am J Pathol 36: 1–17
Lindberg R (1955) Compression of brain arteries as pathogenetic factor for tissue necrosis and their areas of pedilection. J Neuropathol Exp Neurol 14: 223–243
Lindberg R (1956) Morphometric and mor-phostatic necrobiosis. Am J Pathol 23:1147–1177
Little JR, Kerr FW, Sundt TM Jr (1974) The role of lysosomes in production of ischemic nerve cell changes. Arch Neurol 30: 448–455
Little JR, Kerr FW, Sundt TM Jr (1974) Significance of neuronal alterations in developing cortical infarction. Mayo Clin Proc 49: 827–837
Little JR, Sundt TM Jr, Kerr FW (1974). Neuronal alterations in developing cortical infarction. An experimental study in monkeys. J Neurosurg 40: 186–198
Little JR, Kerr FW, Sundt TM Jr (1975) Microcirculatory observation in focal cerebral ischemia. An electron microscopic investigation in monkeys. Stroke 7: 25–30
Matakas F, Cervos-Navarro J, Schneider H (1973) Experimental brain death. 1. Morphology and fine structure of the brain. J Neurol Neurosurg Psychiatry 36: 497–508
McGee-Russell SM, Brown AW, Brierley JB (1970) A combined light and electron microscope study of early anoxic-ischemic cell change in rat brain. Brain Res 20: 193–200
Meyer JS (1958) Importance of ischemic damage to small vessels in experimental cerebral infarction. J Neuropathol Exp Neurol 17: 571–585
Mies G, Niebuhr I, Hossmann KA (1981) Simultaneous measurement of blood flowand glucose metabolism by autoradiographic techniques. Stroke 12: 581–588
Mizoi K, Ogawa A, Seki H et al (1980) Changes of tissue pH in dog during ischemia-Alkaline shift. No To Shinkei 32: 265–268
Nishijima M, Tanaka S, Watanabe T et al (1981) Sequential changes in nerve cells during complete ischemia and the preventive effects of various drugs on cerebral infarction. No To Shinkei 33: 291–299
Ohishi H, Koshu K, Yoshimoto T et al (1981) Contrast enhancement on computed tomography in experimental cerebral infarction in dog. Jpn J Stroke 3: 23–26
Ohishi H, Watanabe T, Seki H et al (1983) Sequential changes of experimental cerebral infarction-CT and histological study. No To Shinkei 35: 983–988
Ohishi H, Nishijima M, Ogawa A et al (1984) Protective effect of mannitol in cerebral infarction-CT findings and physiological observation in experimental cerebral infarction in dogs. No Shinkei Geka 12: 153–158
Petito CK (1979) Platelet thrombi in experimental cerebral infarction. Stroke 10: 192–196
Petito CK, Babiak T (1982) Early proliferative changes in astrocytes in postischemic non infarcted rat brain. Ann Neurol 11: 510–518
Pulsinelli WA, Brierley JB (1979) A new method of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10: 267–272
Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498
Schneider H, Dralle J (1973) Ultrastructural changes in the rat spinal cord after temporary occlusion of the thoracic aorta. Acta Neuropathol (Berl) 26: 301–315
Scholtz W (1959) The contribution of pathoanatomical research to problem of epilepsy. Epilepsia 1: 36–55
Seki H, Ogawa A, Tanaka S et al (1980) Correlation between the thalamus EEG and rCBF in the thalamus infarction in the dogs. No To Shinkei 32: 1065–1069
Spielmeyer W (1922) Histopathologic des Nervensystems. Springer, Berlin
Suzuki M, Iwasaki Y, Yamamoto T et al (1984) Disintegration of orthogonal arrays in perivascular astrocytic processes as an early event in acute global ischemia. Brain Res 300: 141–145
Tureen LL (1936) Effect of experimental temporary vascular occlusion on the spinal cord: correlation between structural and functional changes. Arch Neurol Psychiat 35: 789–807
Watanabe T, Yoshimoto T, Tanaka S et al (1979) Ultrastructural observation of infarction changes of cerebral tissue in dog I. Neuronal alterations. Neurol Med Chir (Tokyo) 19: 279–285
Watanabe T, Yoshimoto T, Koshu K et al (1979) Ultrastructural observation on the infarctic sequential changes in the cerebral tissue of dog-II. changes in small vessels. Neurol Med Chir (Tokyo) 19: 811–816
Watanabe T, Suzuki M, Yoshimoto T et al (1985) Recirculation in ischemic focus in the acute stage-electron microscopical examination. Neurol Med Chir (Tokyo) 25: 81–88
Welsh FA, Rieder W (1978) Evaluation of in situ freezing of cat brain by NADH fluorescence. J Neurochem 31: 299–309
Yoshimine T, Morimoto K, Yanagihara T (1982) Immunohistochemical investigation on cerebral ischemia. Stroke 13: 119
Yoshimine T, Yanagihara T (1983) Regional cerebral ischemia by occlusion of the posterior communicating artery and of the middle cerebral artery in gerbils. J Neu-rosurg 58: 362–367
Yoshimoto T, Sakamoto T, Suzuki J (1978) Experimental cerebral infarction. Part I. Production of thalamic infarction in dogs. Stroke 9: 211–214
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Suzuki, J. (1987). Histological Study. In: Treatment of Cerebral Infarction. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8861-3_3
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DOI: https://doi.org/10.1007/978-3-7091-8861-3_3
Publisher Name: Springer, Vienna
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