Skip to main content
SpringerLink
Log in

Medical Treatment of Cerebral Infarction

  • Chapter
Treatment of Cerebral Infarction

  • 75 Accesses

Abstract

In the treatment of cerebral infarction, it is of course important to distinguish between the prevention and the treatment of the underlying lesions which give rise to cerebral infarction, but in clinical practice the basis for treatment normally focuses on two problems: how to minimize cerebral edema and how to prevent progression of the lesion to a state of infarction. For these purposes, various drug therapies have been developed, but there are as yet few techniques which have been shown to be theoretically and experimentally sound and clinically effective. In practice, it is therefore necessary first to come to a sufficient understanding of the changing cerebral pathology of each patient, and then to undertake control of blood pressure, cerebral edema, etc., in order to maintain appropriate cerebral blood flow and control of the patient's systemic condition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Acheson J (1971): Factors affecting the natural history of focal cerebral vascular disease. Q J Med 40: 25–46

    PubMed  CAS  Google Scholar 

  2. Baker RN, Broward JH, pang HC et al (1962): Anticoagulant therapy in cerebral infarction: report of a co-operative study. Neurology (Minneap) 12: 823–835

    CAS  Google Scholar 

  3. Baskin DS, Hosobuchi Y (1981): Naloxone reversal of ischemic neurological deficits in man. Lancet 2: 272–275

    Article  PubMed  CAS  Google Scholar 

  4. Beevers DG, Fairman MJ, Hamilton M et al (1973): Antihypertensive treatment and the course of established cerebral disease. Lancet 1: 1407–1409

    Article  PubMed  CAS  Google Scholar 

  5. Bousser MG, Eschwege E, Hauenau M et al (1983) AICLA“controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia. Stroke 14: 5–14

    Article  PubMed  CAS  Google Scholar 

  6. Canadian Cooperative Study Group (1978): A randomized trial of aspirin and sul-flnphrazone in threatened stroke. N Engl J Med 299: 53–59

    Article  Google Scholar 

  7. Carter AB (1961): Anticoagulant treatment in progressing stroke. Br Med J 52: 70–73

    Article  Google Scholar 

  8. Carter AB (1970): Hypotensive therapy in stroke survivors. Lancet 1: 485–489

    Article  PubMed  CAS  Google Scholar 

  9. Dyken M, White PT (1956): Evaluation of cortisone in treatment of cerebral infarction. JAMA 162: 1531–1534

    Article  Google Scholar 

  10. Fields W, Lemak NA, Frankowski RF et al (1977): Controlled trial of aspirin in cerebral ischemia. Stroke 8: 301–316

    Article  PubMed  CAS  Google Scholar 

  11. Fisher CM (1982): Management of occlusive cerebrovascular disease. In: Ropper AH, Kennedy SK et al (eds) Neurological and neurosurgical intensive care. University Park Press, Baltimore, pp 189–205

    Google Scholar 

  12. Fletcher AP, Alkjaersig N, Lewis M et al (1976): A pilot study of urokinase therapy in cerebral infarction. Stroke 7: 135–142

    Article  PubMed  CAS  Google Scholar 

  13. Harter HR, Burch N, Majerus PW et al (1979): Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med 301: 577–579

    Article  PubMed  CAS  Google Scholar 

  14. Heck AF (1984): Medical management of TIAs and small strokes. In: Smith RR (ed): Stroke and the extracranial vessels. Raven Press, New York’ pp 149–158

    Google Scholar 

  15. Hutchinson EC (1983): Management of cerebral infarction. In: Russel RWR (ed) Vascular disease of the central nervous system, edn 2, Churchill Livingstone, Edinburgh London Melbourne New York, pp 185–203

    Google Scholar 

  16. Genton E, Barnett HJM, Fields WS et al (1977): Cerebral ischemia: The role of thrombosis and of antithrombotic therapy. Stroke 8: 150–175

    Article  PubMed  CAS  Google Scholar 

  17. Katzman R, Clasen R, Klatzo I et al (1977): Brain edema in stroke. Stroke 8: 512–540

    Article  PubMed  CAS  Google Scholar 

  18. Kuriyama Y, Sawada T, Yamaguchi T et al (1980): Induced hemodilution in acute stage of cerebral infarction, its pathophysiological and therapeutic consideration. Jpn J Stroke 2: 309–315 (Eng Abstr)

    Article  Google Scholar 

  19. Matthews WB, Oxbury JM, Grainger KMR et al (1976): A blind controlled trial of dextran 40 in the treatment of ischemic stroke. Brain 99: 193–206

    Article  PubMed  CAS  Google Scholar 

  20. Meyer JS, Charney JZ, Mathew NT (1971): Treatment with glycerol of cerebral edema due to acute cerebral infarction. Lancet 2: 993–997

    Article  PubMed  CAS  Google Scholar 

  21. Meyer JS, Fukuuchi Y, Shimazu J et al (1972): Effect of intravenous infusion of glycerol on hemispheric blood flow and metabolism in patients with acute cerebral infarction. Stroke 3: 167–180

    Google Scholar 

  22. Meyer JS, Gilroy JG, Barnhart MI et al (1963): Therapeutic thrombosis in cerebral thromboembolism. Neurology 13: 927–937

    PubMed  CAS  Google Scholar 

  23. Millikan CH (1971): Reassessment of anticoagulant therapy in various types of occlusive cerebrovascular disease. Stroke 2: 201–208

    Article  PubMed  CAS  Google Scholar 

  24. Minematsu K, Yamaguchi T, Kuryama Y et al (1983): Clinical application of barbiturate therapy for cerebral infarction: a preliminary report. Jpn J Stroke 5: 286–294

    Article  Google Scholar 

  25. Mizoi M, Oba M, Fujimoto S et al (1984): An experimental study on the protective effect of nizofenone in cerebral ischemia. No To Shinkei 36: 1089–1093

    PubMed  CAS  Google Scholar 

  26. Mulley G, Wilcox RG, Mitchell JRA (1978): Dexamethasone in acute stroke. Br Med J 2: 994–996

    Article  PubMed  CAS  Google Scholar 

  27. Patten BM, Mendell J, Bruun B et al (1972): Doubleblind study of the effects of dexamethasone on acute stroke. Neurology 22: 337–383

    Google Scholar 

  28. Rockoff MA, Marshall LF, Shapiro HM (1979): High-dose barbiturate therapy in humans: a clinical review of 60 patients. Ann Neurol 6: 194–199

    Article  PubMed  CAS  Google Scholar 

  29. Sandok BA, Furlan AJ, Whisnant JP et al (1978): Guidelines for the management of transient ischemic attacks. Mayo Clin Proc 53: 665–674

    PubMed  CAS  Google Scholar 

  30. Satake K, Kondo H, Fukase M (1979): A double-blind study on the clinical efficacy of urokinase in treatment of patients with cerebral infarction. In: Yamori et al (eds) Prophylactic approach to hypertensive disease. Perspective in Cardiovascular Reseach 4: 433–440

    Google Scholar 

  31. Smith AL, Hoff JT, Nielsen SL et al (1974) Barbiturate protection in acute focal cerebral ischemia. Stroke 5: 1–5

    Article  PubMed  CAS  Google Scholar 

  32. Smith AL (1977) Barbiturate protection in cerebral hypoxia. Anesthesiology 47: 285–293

    Article  PubMed  CAS  Google Scholar 

  33. Sorensen PS, Pedersen H, Marquardsen J et al (1983) Acetylsalicylic acid in the prevention of stroke in patients with reversible cerebral ischemic attacks: a Danich cooperative study. Stroke 14: 15–22

    Article  PubMed  CAS  Google Scholar 

  34. Suzuki J, Fujimoto S, Mizoi K et al (1984) The protective effect of combined administration of anti-oxidants and perfluorochemicals on cerebral ischemia. Stroke 15: 672–679

    Article  PubMed  CAS  Google Scholar 

  35. Suzuki TA, Yoshimoto T et al (1985) Use of balloon occlusion and substances to protect ischemic brain during resection of posterior fossa AVM: case report. J Neurosurg 63: 626–629

    Article  PubMed  CAS  Google Scholar 

  36. Tamura A, Asano T, Sano K et al (1979) Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital: a comparative study in chronic MCA occlusion in cats. Stroke 10: 126–134

    Article  PubMed  CAS  Google Scholar 

  37. Yatsu FM, Diamond I, Graziano C et al (1972) Experimental brain ischemia: protection from irreversible damage with a rapid-acting barbiturate (methohexital). Stroke 3: 726–732

    Article  PubMed  CAS  Google Scholar 

  38. Yatsu FM (1975) Protective effects of barbiturates on cerebral ischemia. In: McLaurin RL (ed) Head injuries, 2nd Chicago Symposium on Neural Trauma. Grune and Stratton, New York, pp 185–187

    Google Scholar 

  39. Yatsu FM (1984) Medical management of complete strokes. In: Smith RR (ed) Stroke and the extracranial vessels. Raven Press, New York, pp 159–166

    Google Scholar 

  40. Whisnant JP, Matsumoto N, Elveback LR (1973) The effect of anticoagulation therapy on the prognosis of patients with transient cerebral ischemic attacks in a community: Rochester, Minnesota 1955 through 1969. Mayo Clin Proc 48: 844–848

    PubMed  CAS  Google Scholar 

  41. Wise BL, Chater N (1962) The value of hypertonic mannitol solution in decreasing brain mass and lowering cerebrospinal fluid pressure. J Neurosurg 19: 1038–1043

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neurosurgery, Institute for Brain Diseases, Tohoku University School of Medicine, Nagamachi, Sendai, Japan

    Professor Jiro Suzuki M.D.

Authors
  1. Professor Jiro Suzuki M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag/Wien

About this chapter

Cite this chapter

Suzuki, J. (1987). Medical Treatment of Cerebral Infarction. In: Treatment of Cerebral Infarction. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8861-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-8861-3_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8863-7

  • Online ISBN: 978-3-7091-8861-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation