Skip to main content
SpringerLink
Log in

Arzneimittel im Alter

  • Chapter
Internistische Geriatrie

  • 27 Accesses

Zusammenfassung

Die Zunahme der älteren Bevölkerung in den letzten Jahrzehnten und die Entwicklung immer neuer Arzneimittel haben dazu geführt, daß der Medikamentenverbrauch im höheren Lebensalter stark angestiegen ist. So wurde in Großbritannien gefunden, daß in der über 75jährigen Bevölkerung etwa dreimal soviele Medikamente verschrieben werden als in der übrigen Bevölkerung und daß die Frauen dieser Altersgruppe etwa doppelt soviele Medikamente einnehmen als die Männer (Law 1976, Hurwitz 1969a). Zu den am häufigsten eingenommenen Medikamenten gehören Entwässerungsmittel (Thiazide), Herzglykoside, Psychopharmaka, Antibiotika, Analgetika, Kortikosteroide und Antikoagulantien.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Amery, A., Berthaux, P., Bulpitt, C., Demyttere, M., de Schaepdryver, A., Dollery, C., Fagard, R., Perette, F., Hellemans, J., Lund-Johansen, P., Mutsers, A., Tuomilehto, J.: Glucose mtolerance during diuretic therapy. Lancet i: 681–683 (1978).

    Article  Google Scholar 

  • Ames, R. P., Peacock, P. B.: Semm cholesterol during treatment of hypertension with diuretic dmgs. Arch. Int. Med. 144: 710–714 (1984).

    Article  CAS  Google Scholar 

  • Ashraf, N., Locksley, R., Arieff, A. L: Thiazide-induced hyponatremia associated with death or neurologic damage m outpatients. Am. J. Med. 70: 1163–1168 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Baskin, W. N., Ivey, K. J., Krause, W. J., Jeffrey, G. E., Gemmell, R. T.: Aspirin-mduced ultrastmctural changes in human gastric mucosa. Ann. Int. Med. 85: 299–303 (1976).

    PubMed  CAS  Google Scholar 

  • Booker, J. A.: Severe symptomatic hyponatremia in elderly outpatients: the role of thiazide therapy and stress. J. Am. Geriatr. Soc. 32: 108–113 (1984).

    PubMed  CAS  Google Scholar 

  • Broil, H., Eberl, R., Sochor, H., Tausch, G.: Verträglichkeit der Langzeittherapie mit Indomethacin. Wien. Klin. Wschr. 84: 421–424 (1972).

    Google Scholar 

  • Byrd, L., Sherman, R. L.: Radiocontrast-induced acute renal failure. Medicine 58: 270–279 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Carmichael, J., Shankel, S. W.: Effects of nonsteroidal antünflammatory drugs on prostaglandins and renal function. Am. J. Med. 78: 992–1000 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Castleden, C. M., George, C. P., Marcer, D., Haller, C.: Increased sensitivity to nitrazepam in old age. Brh. Med. J. 1: 10–12 (1977).

    Article  CAS  Google Scholar 

  • Clive, D. M., Stoff, J. S.: Renal syndroms associated with nonsteroidal antünflammatory drugs. New Engl. J. Med. 310: 563–572 (1984).

    CAS  Google Scholar 

  • Cockcroft, D. W., Gault, M. H.: Prediction of creatmin clearance from serum creatinm. Nephron 16: 31–41 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Cusack, B., Kelly, J., O’Malley, K., Noel, J., Lavan, J., Horgan, J.: Digoxin in the elderly: pharmacokmetic consequences of old age. Clm. Pharm. Therap. 25: 772–776 (1979).

    CAS  Google Scholar 

  • Doering, W.: Qumidine-Digoxin interaction. New Engl. J. Med. 301: 400–404 (1979).

    CAS  Google Scholar 

  • Düsing, R., Kipnowski, J., Kramer, H. J.: Prostaglandins and renal Na Cl excretion in healthy human subjects: effects of prostaglandin synthesis inhibition with indomethacin. Khn. Wschr. 60: 1229–1233 (1982).

    Article  Google Scholar 

  • Elkayam, U., Parikh, K., Torkan, B., Weber, L., Cohen, J. L., Rahimtoola, S. H.: Effect of dütiazem on renal clearance and serum concentration of digoxin in patients with cardiac disease. Am. J. Cardiol. 55: 1393–1395 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Emkey, R. D., Mills, J. A.: Aspirin and analgesic nephropathy. J.A.M.A. 247: 55–57 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Epstein, M.: Effects of aging on the kidney. Fed. Proc. 38: 168–172 (1979).

    PubMed  CAS  Google Scholar 

  • Falch, D.: The influence of kidney function, body size and age on plasma concentration and urinary excretion of digoxin. Acta Med. Scand. 194: 251–256 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Farah, F., Taylor, W., Rawlins, M. D., James, O.: Hepatic drug acetylation and oxidation: effects of aging in man. Brit. Med. J. 2: 155–156 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Finnegan, T. P., Spence, J. D., Cape, R. D.: Potassium-sparing diuretics: interaction with digoxin in elderly man. Brh. Med. J. 2: 155–156 (1977).

    Article  Google Scholar 

  • Garella, S., Matarese, R. A.: Renal effects of prostaglandins and cHnical adverse effects of nonsteroidal antiinflammatory agents. Medicine 63: 165–181 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Gillum, R. F., Barsky, A. J.: Diagnosis and managment of patients noncompliance. J.A.M.A. 228: 1563–1567 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Goldman, A. I., Steele, B. W., Schnaper, H. W., Fitz, A. E., Frowich, E. D., Perry, H. M.: Serum hpoprotein levels during chlorthalidone therapy. J. A. M. A. 244: 1691–1695 (1980)

    Article  PubMed  CAS  Google Scholar 

  • Greenblatt, D. J., Sehers, E. M., Shader, R. I.: Drug therapy: drug disposition in old age. New Engl. J. Med. 306: 1081–1088 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Hartmann, H., Fischer, G., Janning, G.: Prolonged cholestatic jaundice and leukopenia associated with Piroxicam. Ztschr. Gastroenterol. 22: 343–345 (1984).

    CAS  Google Scholar 

  • Henschke, P. J., Spence, J. D., Cape, R. D. T.: Diuretics and the institutional elderly: a case against routine potassium prescribing. J. Am. Geriatr. Soc. 29: 145–150 (1981).

    PubMed  CAS  Google Scholar 

  • Hurwitz, N.: Admissions to hospital due to drugs. Brh. Med. J. 1: 539–540 (1969a).

    Article  CAS  Google Scholar 

  • Hurwitz, N.: Predisposing factors in adverse reactions to drugs. Brit. Med. J. 1: 536–539 (1969b)

    Article  PubMed  CAS  Google Scholar 

  • Inman, W. H. W.: Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone. Brh. Med. J. 1: 1500–1505 (1977).

    Article  CAS  Google Scholar 

  • Iseri, L. T., Freed, J., Bures, A. R.: Magnesium deficiency and cardiac disorders. Am. J. Med. 58:837–846 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Khalil, S. A. H.: The uptake of digoxin and digitoxin by some antacids. J. Pharm. Pharmacol. 26: 961–967 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Kiernan, P. J., Isaacs, J. B.: Use of drugs by the elderly. J. Roy. Soc. Med. 74: 196–200 (1980)

    Google Scholar 

  • Klein, H. O., Lang, R., Weiss, E., DiSegni, E., Libhaber, C., Guerrero, J., Kaplinsky, E.: The influence of verapamil on serum digoxin concentration. Circulation 65: 998–1003 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Klotz, U., Avant, G. R., Hoyumpa, A., Schenker, S., Wilkinson, G. R.: The effects of age and hver disease on the disposition and elimination of diazepam in adult man. J. Chn. Invest. 55: 347–359 (1975).

    Article  CAS  Google Scholar 

  • Koenig, W., Kreil, U., Stieber, J., Döring, A., Pöppl, S. J., Mraz, W.: Zur Epidenüologie der Dighahsmedikation. Dtsch. Med. Wschr. 109: 412–418 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Kraupp, O.: Pharmakodynamische Beeinflussung der Rhythmik, Dynamik und Durchblutung des Herzens. In: Allgemeine und spezielle Pharmakologie und Toxikologie (Forth, W., Henschler, D., Rummel, W., Hrsg.), S. 192–26O. Mannheim: Wissenschaftsverlag Bibhographisches Institut 1983.

    Google Scholar 

  • Kuhlmann, J.: Plasmaspiegel und renale Elimination von Digitoxin bei Langzeittherapie mit Aluminium-Magnesium-Hydroxyd-Gel. Dtsch. Med. Wschr. 109: 59–61 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Kühn, P., Hohenwallner, W., Wimmer, E., Sommer, R.: Digoxin Screening bei Spitalsaufnahme. Wien. Klin. Wschr. 92: 356–360 (1980).

    PubMed  Google Scholar 

  • Kühn, P.: Therapie der Herzinsuffizienz im Alter. Öst. Ärzteztg. 38: 763–766 (1983).

    Google Scholar 

  • Law, R., Chalmers, C.: Medicines and elderly people: a general practice survey. Brit. Med. J. 1: 565–568 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial results. L Reduction in incidence of coronary heart disease. J.A.M.A. 251: 351–364 (1984)

    Article  Google Scholar 

  • Madias, N. E., Zelman, S. J.: What are the metabohc complications of diuretic treatment? Geriatrics 37/2: 93–104 (1982).

    PubMed  CAS  Google Scholar 

  • Manyari, D. E., Patterson, C., Johnson, D. E., Melendez, L. J.: Quinidine therapy and digitalis toxicity. J. Am. Geriatr. Soc. 29: 31–33 (1981).

    PubMed  CAS  Google Scholar 

  • Middeke, M., Meister, W., Krüger, C., Krahl, B., Holzgreve, H.: Digita Ustherapie: Verschrei- bungshäufigkeit, Serumkonzentrationen und Auslaßversuch. Klin. Wschr. 63: 775–780 (1984)

    Article  Google Scholar 

  • Mitchell, J. R., McMurtry, R. J., Statham, C. N., Nelson, S. D.: Molecular basis for several drug-induced nephropathies. Am. J. Med. 62: 518–526 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Murphy, M. B., Lewis, P. J., Kohner, E., Schumer, B., Dollery, C. T.: Glucose intolerance in hypertensive patients treated with diuretics; a fourteen-year follow-up. Lancet ii: 1293–1295 (1982).

    Article  Google Scholar 

  • Novak, L. P.: Aging, total body potassium, fat free mass, and cell mass in males and femáis between ages 18 and 85 years. J. Gerontol. 27: 438–448 (1972).

    PubMed  CAS  Google Scholar 

  • Ochs, H. R., Bodem, G.: Einfluß des Alters auf die Kinetüc von Diazepam und Desmethyldiazepam. Verh. Dtsch. Ges. Inn. Med. 86: 1231–1233 (1980).

    CAS  Google Scholar 

  • Ouslander, J. G.: Drug therapy in the elderly. Ann. Int. Med. 95: 711–722 (1981).

    PubMed  CAS  Google Scholar 

  • Portnoi, V. A., Pawlson, L. G.: Abuse of diuretic therapy in nursing homes. J. Chron. Dis. 34: 363–365 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Reidenberg, M. M., Levy, M., Warner, H., Coutinho, C. B., Schwartz, M.A., Yu, G., Cheripko, J.: Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clin. Pharm. Therap. 23: 371–374 (1978).

    PubMed  CAS  Google Scholar 

  • Sakai, J., Joseph, M. W.: Tolmetin and agranulocytosis. New Engl. J. Med. 298: 1203 (1978).

    PubMed  CAS  Google Scholar 

  • Schmucker, D. L.: Drug disposition in the elderly. J. Am. Geriatr. Soc. 32: 144–149 (1984).

    PubMed  CAS  Google Scholar 

  • Sünon, L. S., Mills, J. A.: Nonsteroidal antünflammatory drugs. New Engl. J. Med. 302: 1179–1185,1237–1243 (1980).

    Google Scholar 

  • Stemess, E.: Diuretics, digitahs and arrhythmias. Acta Med. Scand. Suppl. 647: 75–78 (1981).

    Google Scholar 

  • Stults, B. M.: Digoxm use in the elderly. J. Am. Geriatr. Soc. 30: 158–164 (1982).

    PubMed  CAS  Google Scholar 

  • Surawicz, B.: Relationship between electrocardiogram and electrolytes. Am. Heart J. 73: 814–834 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Szczekhk, A., Gryglewski, R. J., Czerniawska-Mysik, G.: Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. J. Allergy Clin. Immunol. 60: 276–284 (1977).

    Article  Google Scholar 

  • Vestal, R. F.: Pharmacology and agmg. J. Am. Geriatr. Soc. 30: 191–200 (1982).

    PubMed  CAS  Google Scholar 

  • Wandless, I., Davie, J. W.: Can drug compliance in the elderly be unproved? Brit. Med. J. 1: 359–361 (1977).

    Article  CAS  Google Scholar 

  • Wemberger, M. H.: Antüiypertensive therapy and lipids. Arch. Int. Med. 145: 1102–1105 (1985).

    Article  Google Scholar 

  • Whang, R., Oei, T. O., Watanabe, A.: Frequency of hypomagnesemia in hospitalized patients receivmg digitahs. Arch. Int. Med. 145: 655–656 (1985).

    Article  CAS  Google Scholar 

  • Wükerson, R. D., Mockridge, P. B., Massmg, G. K.: Effects of selected drugs on serum digoxin concentration in dogs. Am. J. Cardiol. 45: 1201–1210 (1980).

    Article  Google Scholar 

  • Wilkinson, G. R.: Drug distribution and renal excretion in the elderly. J. Chron. Dis. 36: 91–102 (1983).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Medizinischen Abteilung, Kaiser-Franz-Joseph-Spitals, Wien, Österreich

    Prof. Dr. Karl Heinz Tragl (Vorstand)

Authors
  1. Prof. Dr. Karl Heinz Tragl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag/Wien

About this chapter

Cite this chapter

Tragl, K.H. (1986). Arzneimittel im Alter. In: Internistische Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8839-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-8839-2_14

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-81904-3

  • Online ISBN: 978-3-7091-8839-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation