The Geographic Distribution of Globin Gene Variation

  • George R. Honig
  • Junius G. AdamsIII


With relatively few exeeptions, the globin gene mutations that are tabulated in the Appendix occur only rarely, with a majority of these mutations having been found in only one or a very limited number of individuals or families. Some of the other globin gene mutations have been shown to occur with relatively high frequency, but only in individuals within highly isolated populations. On the other hand, the group that includes Hb S, Hb C, Hb E, and the thalassemias includes enormous numbers of people and extends over a very wide geographical area. (For a more detailed account see Bowman, 1983, and Winter, 1985).


Cerebral Malaria Globin Gene Parasite Growth Malarial Parasite Endemic Malaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag/Wien 1986

Authors and Affiliations

  • George R. Honig
    • 1
  • Junius G. AdamsIII
    • 2
    • 3
  1. 1.Department of Pediatrics, College of MedicineUniversity of IllinoisChicagoUSA
  2. 2.Hemoglobin Research LaboratoryVA Medical CenterJacksonUSA
  3. 3.Department of MedicineUniversity of Mississippi School of MedicineJacksonUSA

Personalised recommendations