The Geographic Distribution of Globin Gene Variation
With relatively few exeeptions, the globin gene mutations that are tabulated in the Appendix occur only rarely, with a majority of these mutations having been found in only one or a very limited number of individuals or families. Some of the other globin gene mutations have been shown to occur with relatively high frequency, but only in individuals within highly isolated populations. On the other hand, the group that includes Hb S, Hb C, Hb E, and the thalassemias includes enormous numbers of people and extends over a very wide geographical area. (For a more detailed account see Bowman, 1983, and Winter, 1985).
KeywordsCerebral Malaria Globin Gene Parasite Growth Malarial Parasite Endemic Malaria
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