The Globin Gene Mutations
The structural hemoglobin variants, thalassemias, and syndromes of hereditary persistence of fetal hemoglobin synthesis produce a remarkable diversity of clinical manifestations. The principal hematologic and clinical features of these conditions are considered briefly in the following sections, with emphasis on the mode of expression of their mutant genes. These disorders have been reviewed extensively in several recent texts (Lehmann and Huntsman, 1974; Serjeant, 1974; Schwartz, 1980; Weatherall and Clegg, 1981).
KeywordsSickle Cell Disease Sickle Cell Trait Oxygen Affinity Heme Pocket Abnormal Hemoglobin
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