Only slightly more than 40 years have elapsed since publication of the classic study of Avery, MacLeod, and McCarty (1944) which first showed that genetic information is stored in the form of deoxyribonucleic acid (DNA). Subsequent milestones in the advancement of knowledge of how DNA fulfills its role as a genetic carrier have included the elucidation of the helical structure of the DNA molecule and the complementary relationship of its base sequences (Watson and Crick, 1953a); the determination of how information encoded in the polynucleotide sequences of the DNA molecule is ultimately translated into polypeptides (Jacob and Monod, 1961); and the delineation of the genetic code (Nirenberg and Leder, 1964) demonstrating the nature and specificity of messenger RNA nucleotide base sequences.
KeywordsGlobin Gene Globin Chain Globin mRNA Human Globin Gene Polynucleotide Sequence
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