It is quite obvious that the preceding chapters are only the first Step into a new exciting field of Ophthalmic diagnosis. This field of exact, reproducible, quantitative corneal esthesiometry is of recent origin and we do not claim that all of its morphologic, neurophysiologic, pharmacologic and pathophysiologic aspects have been covered. The longer we have used this new examination method, the more manifold have become the various possibilities of applying it. New questions have arisen and more questions have been asked by other investigators. The testing of Compounds which originally had apparently nothing to do with corneal sensitivity brought new and unexpected results. This led us into the field of human genetics and pharmaeokinetie research. The numerous problems of corneal wound healing, not only in connection with keratoplasty, have not yet been exhaustively investigated. A rich harvest of clinical applications should result from these investigations. We shall continue our examinations on the possibility that corneal sensitivity may be an indicator for a beginning diabetic polyneuropathy perhaps giving us a lead as to the diabetic control. This question has not yet been completely resolved. Further investigations are necessary to evaluate the most interesting results after a surgical retinal detachment procedure. These may be of pathophysiologic and clinical importance. The same holds for the fitting of contact lenses: We may be dealing here not only with a possible predictive factor which would indicate whether the patient can tolerate a contact lens or not, but this examination method may also be of value for patients who have worn contact lenses for a long period of time. Increased thresholds could indicate a threatening complication. The use of this examination method in connection with the use of preserved corneal buttons in corneal transplant Operations has opened a new field of application: In addition to the usual methods of evaluating the corneal endothelium and measuring corneal thickness, the esthesiometry may give us a further indication as to the trophic condition of the corneal transplant.