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Morphology of Intracranial Tumours and Adjacent Brain Structures Following Interstitial Iodine-125 Radiotherapy

  • M. Kiessling
  • P. Kleihues
  • E. Gessaga
  • F. Mundinger
  • Ch. B. Ostertag
  • K. Weigel
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 33)

Summary

Analysis of 8 autopsied cases with permanent 125I implantation demonstrates that interstitial irradiation of CNS neoplasms causes extensive focal tumour necroses. In some cases, complete tumour regression resulted, with no viable neoplastic cells detectable at autopsy. In large gliomas of the cerebral hemispheres and basal ganglia, central radiation-induced necroses were present, but peripheral tumour masses progressed and ultimately determined the clinical outcome. In patients with tumours located in basal midline structures, interstitial 125I produced areas of delayed radionecrosis extending into the adjacent normal brain tissue. All of these patients were treated with external radiation in addition to interstitial implantation, indicating cumulative radiation toxicity.

Keywords

Anaplastic Astrocytoma Complete Tumour Regression Radioactive Seed Permanent Implantation Interstitial Irradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. Kiessling
    • 1
  • P. Kleihues
    • 1
  • E. Gessaga
    • 3
  • F. Mundinger
    • 2
  • Ch. B. Ostertag
    • 2
  • K. Weigel
    • 2
  1. 1.Abteilung Neuropathologie, Pathologisches InstitutUniversität FreiburgFederal Republic of Germany
  2. 2.Abteilung Stereotaxie und Neuronuklearmedizin, Neurochirurgische KlinikUniversität FreiburgFederal Republic of Germany
  3. 3.Pathologisches InstitutKantonsspital AarauSwitzerland

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