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Mechanisms of Suppression by DNA Methylation

  • James Herbert Taylor
Part of the Cell Biology Monographs book series (CELLBIOL, volume 11)

Abstract

We have cited a number of studies showing an inverse correlation between the level of methylation and function of a number of genes. What then is the nature of this correlation? The assumption usually is that DNA methylation is the initial event and suppression follows. However, some of the data are just as easily explained on the assumption that function turned off by some other mechanism makes the gene susceptible to methylation and there may not be a cause and effect relationship between methylation and gene activity. As long as the evidence was based only on correlation of the two properties, expression and the unmethylated State, this possibility had to be considered. Recently, however, a cause and effect relationship has been more firmly established.

Keywords

Methylation Pattern Globin Gene CCGG Site Okazaki Fragment HpaII Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1984

Authors and Affiliations

  • James Herbert Taylor
    • 1
  1. 1.Institute of Molecular BiophysicsThe Florida State UniversityTallahasseeUSA

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