Mechanisms of Suppression by DNA Methylation
We have cited a number of studies showing an inverse correlation between the level of methylation and function of a number of genes. What then is the nature of this correlation? The assumption usually is that DNA methylation is the initial event and suppression follows. However, some of the data are just as easily explained on the assumption that function turned off by some other mechanism makes the gene susceptible to methylation and there may not be a cause and effect relationship between methylation and gene activity. As long as the evidence was based only on correlation of the two properties, expression and the unmethylated State, this possibility had to be considered. Recently, however, a cause and effect relationship has been more firmly established.
KeywordsMethylation Pattern Globin Gene CCGG Site Okazaki Fragment HpaII Site
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