DNA Methylation and Cell Differentiation: An Overview
The problem of cellular differentiation has renewed interest for molecular biologists who are studying the modifications of DNA. Three modifications are getting much of the attention. One is a structural modification of the one dimensional message by the insertion of transposable genetic elements. Another is a base modification by methylation which does not alter the one-dimensional coding properties, but may change the affinity for other molecules and thereby transcription or readout of the code. The third is a new three dimensional structural form called Z-DNA which is related to the base sequence, the modification by methylation, the torsional properties and the molecular environment. This change would affect affinity for other molecules and could also affect the readout of the code.
KeywordsImaginal Disk Mobile Genetic Element Disk Cell Break Chromosome Genome Modification
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