Abstract
The genomes of influenza A and B viruses are comprised of 8 single-stranded RNA segments of different molecular weights, while influenza C viruses contain only 7 segments (for reviews see Palese, 1977; Scholtissek, 1978, 1979a; Palese et al., 1980). This unusual structure of the influenza virus genome makes a genetic comparison of different isolates interesting, because during double infection of a host with two different strains of the same type, each RNA segment behaves like a chromosome, and free reassortment is possible, creating new strains. Thus, when comparing two strains, each pair of allelic RNA segments has to be studied separately.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaronson, P.P., Young, J. F., Palese, P.: Oligonucleotode mapping: evaluation of its sensitivity by computer-simulation. Nucl. Acids Res. 10, 237–246 (1982).
Air, G.: Nucleotide sequence coding for the “signal peptide” and N terminus of the hemagglutinin of an Asian (H2N2) strain of influenza virus. Virology 97, 468–472 (1979).
Air, G. M.: Sequence relationships among the hemagglutinin genes ofl2 subtypes of influenza A virus. Proc. Natl. Acad. Sci. U.S.A. 78, 7639–7643 (1981).
Air, G. M., Hackett, J. A.: Gene 8 of influenza virus: sequences of NA transcribed from the 3’ ends of viral RNA of influenza A and B strains. Virology 103, 291–298 (1980).
Allen, H., Mauley, J., Waterfield, M., Gething, M.-J.: Influenza virus RNA segment 7 has the coding capacity for two polypeptides. Virology 107, 548–551 (1980).
Almond, J. W., Barry, R. D.: Genetic recombination between two strains of fowl plague virus: construction of generic maps. Virology 92, 407–415 (1979).
Baez, M., Taussig, R., Zazra, J.J., Young, J. F., Palese, P.: Complete nucleotide sequence of the influenza A/PR/8/34 virus NS gene and comparison with the NS genes of the A/Udorn/72 and A/FPV/Rostock/34 strains. Nucl. Acids Res. 8, 5845–5858 (1980).
Baez, M., Zazra, J.J., Elliott, R.M., Young, J. F., Palese, P.: Nucleotide sequence of the influenza A/duck/Alberta/60/76 virus NS RNA: conservation of the NS1/NS2 overlapping gene structure in a divergent influenza virus RNA segment. Virology 113, 397–402 (1981).
Bean, W. J., Sriram, G., Webster, R. G.: Electrophoreric analysis of iodine-labeled influenza virus RNA segments. Analyt. Biochem. 102, 228–232 (1980a).
Bean, W.J., Cox, N.J., Kendal, A. P.: Recombination of human influenza A viruses in nature. Nature 284, 638–640 (1980b).
Bean, W.J., Hinshaw, V. S., Webster, R. G.: Genetic characterization of an influenza virus from seals. In: The Replication of Negative Strand Viruses (Bishop, D.H. L., Compans, R.W., eds.), 363–367. New York-Amsterdam-Oxford: Elsevier/North-Holland 1981.
Bishop, D.H.L., Huddleston, J. A., Brownlee, G.G.: The complete sequence of RNA segment 2 of influenza A/NT/60/68 and its encoded PI protein. Nucl. Acids Res. 10, 1335–1343 (1982).
Blok, J., Air, G. M.: Comparative nucleoride sequences at the 3’ end of the neuraminidase gene from eleven influenza A viruses. Virology 107, 50–60 (1980).
Blok, J., Air, G. M.: Block deletions in the neuraminidase genes from some influenza A viruses of the N1 subtype. Virology 118, 229–234 (1982).
Blok, J., Air, G. M., Laver, W. G., Ward, C. W., Lilley, G. G., Woods, E. F., Roxburgh, C. M., Inghs, A. S.: Studies on the size, chemical composition, and partial sequence of the neuraminidase (NA) from type A influenza viruses show that the N terminal region of the NA is not processed and serves to anchor the NA in the viral membrane. Virology 119, 109–121 (1982).
Bosch, F. X., Orlich, M., Klenk, H.-D., Rott, R.: The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses. Virology 95, 197–207 (1979).
Bosch, F.X., von Hoyningen-Huene, V., Scholtissek, C., Rott, R.: The overall evolution of the H7 influenza virus hemagglutinin is different from the evolution of the proteolytic cleavage site. J. Gen. Virol. 61,101–104 (1982).
Both, G. W., Sleigh, M.J.: Complete nucleotide sequence of the hemagglutinin gene from a human influenza virus of the Hong Kong subtype. Nucl. Acids Res. 8, 2561–2575 (1980).
Both, G. W., Sleigh, M.J.: Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic drift. J. Virol. 39, 663–672 (1981).
Both, G.W., Sleigh, M.J., Bender, V.J., Moss, B. A.: A comparison of antigenic variation in Hong Kong influenza virus hemagglutinins at the nucleic acid level. In: Structure and Variation in Influenza Virus (Laver, G., Air, G., eds.), 81–89. New York-Amsterdam-Oxford: Elsevier/North- Holland 1980.
Briedis, D.J., Lamb, R. A.: Influenza B virus genome: Sequences and structural organization of RNA segment 8 and the NAs coding for the NSl and NS2 proteins. J. Virol. 42, 186–193 (1982).
Briedis, D.J., Lamb, R.A., Choppin, P.W.: Sequence of RNA segment 7 of the influenza B virus genome: partial amino acid homology between the membrane proteins (Ml) of influenza A and B viruses and conservation of a second open reading frame. Virology 116, 581–588 (1982).
Bucher, D. J., Li, S. S.-L., Kehoe, J. M., Kilbourne, E. D.: Chromatographic isolation of the hemagglutinin polypeptides from influenza virus vaccine and determination of their amino-terminal sequences. Proc. Natl. Acad. Sci. U.S.A. 78, 238–242 (1976).
Desselberger, U., Palese, P.: Molecular weights of RNA segments of influenza A and B viruses. Virology 88, 394–399 (1978).
Desselberger, U., Nakajima, K., Alfmo, P., Pedersen, F. S., Haseltine, W. A., Hannoun, C., Palese, P.: Biochemical evidence that “new” influenza virus strains in nature may arise by recombination (reassortment). Proc. Natl. Acad. Sci. U.S.A. 75, 3341–3345 (1978).
Desselberger, U., Racaniello, V.R., Zazra, J.J., Palese, P.: The 3’ and 5’-terminal sequences of influenza A, B, and C virus RNA segments are highly conserved and show partial inverted complementarity. Gene 8, 315–328 (1980).
De Wächter, R., Fiers, W.: Preparative two-dimensional polyacrylamide gel electrophoresis of 32P- labeled RNA. Analyt. Biochem. 49, 184–197 (1972).
Dimmock, N.J., Carver, A. S., Webster, R. G.: Categorization of nucleoproteins and matrix proteins from type A influenza viruses by peptide mapping. Virology 103, 350–356 (1980).
Donis-Keller, H., Maxam, A. M., Gilbert, W.: Mapping adenines, guanines, and pyrimidines in RNA. Nucl. Acids Res. 4, 2527–2538 (1977).
Dopheide, T. A. A., Ward, C. W.: Studies on the primary structure of the hemagglutinin from an H3N2 variant A/Memphis/102/72. In: Topics in Infectious Diseases, Vol. 3: The Influenza Virus Hemagglutinin (Laver, W. G., Bachmayer, H., Weil, R., eds.), 193–201. Wien-New York: Springer 1978 a.
Dopheide, T. A., Ward, C. W.: The carboxyl-terminal sequence of the heavy chain of a Hong Kong influenza hemagglutinin. Eur. J. Biochem. 85, 393–398 (1978 b).
Dopheide, T. A. A., Ward, C. W.: A Hong Kong influenza hemagglutinin light chain: The amino acid sequence of cyanogen bromide fragments CN3 and CN4 and the N terminal 45 residues. Virology 92, 230–235 (1979).
Dopheide, T. A., Ward, C. W.: Stmctural studies on a Hong Kong hemagglutinin. The Structure of the light chain and the arrangement of the disulphide bonds. In: Structure and Variation in Influenza Virus (Laver, G., Air, G., eds.), 21–26. New York-Amsterdam-Oxford: Elsevier/North-Holland 1980 a.
Dopheide, T. A., Ward, C. W.: The amino acid sequence of a Hong Kong influenza hemagglutinin light (HA2) chain. J. Gen. Virol. 50, 329–335 (1980 b).
Dopheide, T. A., Ward, C. W.: The location of the bromelain cleavage site in a Hong Kong influenza hemagglutinin. J. Gen. Virol. 52, 362–370 (1981).
Emtage, J. S., Catlin, G. H., Carey, N. H.: Polyadenylation and reverse transcription of influenza viral RNA. Nucl. Acids Res. 6, 1221–1239 (1979).
Fang, R., Min Jou, W., Huylebroeck, D., Devos, R., Fiers, W.: Complete Structure of A/duck/Ukraine/ 63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin. Cell 25, 315–323 (1981).
Fields, S., Winter, G.: Nucleotide sequence of influenza virus segments 1 and 3 reveal mosaic structure ofa small viral RNA segment. Cell 28, 303–313 (1982).
Fields, S., Winter, G., Brownlee, G. G.: Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Nature 290, 213–217 (1981).
Frisby, D.: Oligonucleotide mapping of non-radioactive virus and messenger RNA. Nucl. Acids Res. 4, 2975–2996 (1977).
Garten, W., Bosch, F.X., Linder, D., Rott, R., Klenk, H.-D.: Proteolytic activation of the influenza virus hemagglutinin: The structure of the cleavage site and the enzymes involved in cleavage. Virology 115, 361–374 (1981).
Garten, W., Linder, D., Rott, R., Klenk, H.-D.: The cleavage site of the hemagglutinin of fowl plague virus. Virology 121,186–190 (1982).
Gething, M.-J., Bye, J., Skehel, J. J., Waterfield, M.: Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus. Nature 287, 301–306 (1980).
Ghendon, Y., Klimov, A., Blagoveshenskaya, O., Genkina, D.: Investigation of recombinants of human influenza and fowl plague viruses. J. Gen. Virol. 43, 183–191 (1979).
Ghendon, Y. Z., Klimov, A. I., Alexandrova, G. I., Polezhaev, F. I.: Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains. J. Gen. Virol. 53, 215–224 (1981 a).
Ghendon, Y., Klimov, A., Gorodkova, N., Dohner, L.: Genome analysis of influenza A virus strains isolated during an epidemic of 1979–1980. J. Gen. Virol. 56, 303–313 (1981b).
Hall, R. M., Air, G. M.: Variation in nucleotide sequences coding for the N terminal regions of the matrix and nonstructural proteins of influenza A viruses. J. Virol. 38, 1–7 (1981).
Harms, E., Rohde, W., Bosch, F., Scholtissek, C.: Biochemical studies on influenza viruses. II. Assignment of gene functions to RNA segments 5, 7, and 8 of fowl plague virus and virus N. Virology 86, 413–422 (1978).
Hay, A.J., Bellamy, A.R., Abraham, G., Skehel, J.J., Brand, C.M., Webster, R.G.: Procedure for characterization of genetic material of candidate vaccine strains. (Int. Symp. Influenza Immunization, 2nd, 1977.) Dev. Biol. Stand. 39, 15–24 (1977).
Heller, E., Scholtissek, C.: Evidence for intracistronic complementation of the product of the influenza virus gene Ptra (P3 of fowl plague virus). J. Gen. Virol. 49, 133–139 (1980).
Hinshaw, VS., Bean, W.J., Webster, R.G., Easterday, B.C.: The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. Virology 84, 51–62 (1978).
Hinshaw, V. S., Bean, W.J., Webster, R. G., Sriram, G.: Genetic reassortment of influenza A viruses in the intestinal tract of ducks. Virology 102, 412–419 (1980).
Hinshaw, V. S., Air, G. M., Gibbs, A. J., Graves, L., Prescott, B., Kamnakaran, D.: Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls. J. Virol. 42, 865–872 (1982).
Hiti, A. L., Nayak, D.P.: Complete nucleotide sequence of the neuraminidase gene of human influenza virus A/WSN/33. J. Virol. 41, 730–734 (1982).
Hiti, A. L., Davis, A. R., Nayak, D. P.: Complete sequence analysis shows that the hemagglutinins of the HO and H2 subtypes of human influenza virus are closely related. Virology 111, 113–124 (1981).
Horisberger, M. A.: The large P proteins of influenza A viruses are composed of one acidic and two basic polypeptides. Virology 107, 302–305 (1980).
Horisberger, M. A.: Identification of a catalytic activity of the large basic P polypeptide of influenza virus. Virology 120, 279–286 (1982).
Huddleston, J. A., Brownlee, G.G.: The sequence of the nucleoprotein gene of human influenza A virus strain A/NT/60/68. Nucl. Acids Res. 10, 1029–1038 (1982).
Hugentobler, A. L., Schild, G. C., Oxford, J. S.: Differences in the electrophoretic migration rates of polypeptides and RNAs of recent isolates of influenza B viruses. Arch. Virol. 69,197–207 (1981).
Kaptein, J.S., Nayak, D.P.: Complete nucleotide sequence of the polymerase 3 gene of human influenza virus A/WSN/33. J. Virol. 42, 55–63 (1982).
Klimov, A. L, Ghendon, Y. Z.: Genome analysis of Hl influenza virus strains isolated in the USSR during an epidemic in 1961–1962. Arch. Virol. 70, 225–232 (1981).
Kozlov, J. v., Gorbulev, V. G., Kurmanova, A. G., Bayev, A. A., Shilov, A. A., Zhdanov, V. M.: On the origin of the Hl (A/USSR/90/77) influenza virus. J. Gen. Virol. 56, 437–440 (1981).
Kmg, R. M.: The unique interaction of influenza viral RNA transcription with the host-cell transcriptional machinery. In: The Origin of Pandemic Influenza Viruses (Laver, W.G., ed.). New York- Amsterdam-Oxford: Elsevier/North-Holland 1983 (in press).
Lamb, R. A., Lai, C.-J.: Sequence of intermpted and unintermpted NAs and cloned DNA coding for the two overlapping nonstmctural proteins of influenza virus. Cell 21, 475–485 (1980).
Lamb, R. A., Choppin, P. W.: Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus. Virology 112, 729–737 (1981).
Lamb, R.A., Lai, C.-J.: Conservation of the influenza virus membrane protein (Ml) amino acid sequence and an open reading frame of RNA segment 7 encoding a second protein (M2) in Hl and H3N2 strains. Virology 112, 746–751 (1981).
Laver, W. G.: Stmctural studies on the protein subunits from three strains of influenza virus. J. Mol. Biol. 9, 109–124 (1964).
Laver, W. G., Webster, R. G.: Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutinating proteins. Virology 34, 193–202 (1968).
Laver, W. G., Webster, R. G.: Studies on the origin of pandemic influenza. IL Peptide maps of the light and heavy polypeptide chains from the hemagglutinin subunits of A2 influenza viruses isolated before and after the appearance of Hong Kong influenza. Virology 48, 445–455
Laver, W. G., Webster, R. G.: Studies on the origin of pandemic influenza. III. Evidence implicating chick and equine influenza viruses as possible progenitors of the Hong Kong strain of human influenza. Virology 51, 383–391 (1973).
Laver, W. G., Air, G. M., Webster, R. G., Gerhard, W., Ward, C. W., Dopheide, T. A. A.: Antigenic drift in type A influenza virus: Sequence differences in the hemagglutinin of Hong Kong (H3N2) variants selected with monoclonal hybridoma antibodies. Virology 98, 226–237 (1979 a).
Laver, W.G., Gerhard, W., Webster, R.G., Frankel, M.E., Air, G.M.: Antigenic drift in type A influenza virus: peptide mapping and antigenic analysis of A/PR/8/34 (HONl) variants selected with monoclonal antibodies. Proc. Nad. Acad. Sci. U.S.A. 76, 1425–1429 (1979 b).
Laver, W. G., Air, G. M., Dopheide, T. A., Ward, C. W.: Amino acid sequence changes in the hemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 1968–1977. Nature 283, 454–457 (1980 a).
Laver, W. G., Air, G. M., Webster, R. G., Gerhard, W., Ward, C. W., Dopheide, T. A. A.: The mechanism of antigenic drift in influenza virus: sequence changes in the hemagglutinin of variants selected with monoclonal hybridoma antibodies. Phil. Trans. R. Soc. (Lond.) B288, 313–326 (1980 b).
Laver, W. G., Air, G. M., Webster, R. G.: Mechanism of antigenic drift in influenza virus. Amino acid sequence changes in an antigenically active region of Hong Kong (H3N2) influenza virus hemaggludnin. J. Mol. Biol. 145, 339–361 (1981).
Markoff, L., Lai, C.-J.: Sequence of the influenza A/Udorn/72 (H3N2) virus neuraminidase gene as determined from cloned flill-length DNA. Virology 119, 288–297 (1982).
Maxam, A.M., Gilbert, W.: A new method for sequencing DNA. Proc. Nad. Acad, Sci. U.S.A. 74, 560–564 (1977).
Mauley, J., Skehel, J. J., Waterfield, M.D.: The Structure of the small polypepdde chain of the hemagglutinin of an Asian influenza virus Japan 305/57-Bellamy/42 (H2N1). In: Topics in Infectious Diseases, Vol. 3: The Influenza Virus Hemagglutinin (Laver, W. G., Bachmayer, H., Weil, R., eds.), 181–192. Wien-New York: Springer 1978.
Mauley, J.W., Mahy, B.W.J., Inglis, S.C.: Nucleotide sequence of fowl plague virus RNA segment 7. J. Gen, Virol. 58, 211–215 (1982).
Meoch, D., Fellner, P., Newton, C.: Influenza virus genome consists of eight distinct RNA species. Proc. Nad. Acad. Sci. U.S.A. 73, 3045–3049 (1976).
Meier-Ewert, H., Petri, T., Bishop, D. H. L.: Oligonucleodde fingerprint analyses of influenza C virion RNA recovered from five different isolates. Arch. Virol. 67, 141–147 (1981).
Min Jou, W., Verhoeyen, M., Devos, R., Saman, E., Fang, R., Huylebroeck, D., Fiers, W.: Complete Structure of the hemaggludnin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell 19, 683–696 (1980).
Nakajima, K., Desselberger, U., Palese, P.: Recent human influenza A (Hl) viruses are closely related genedcally to strains isolated in 1950, Nature 274, 334–339 (1978).
Nakajima, K., Nakajima, S., Sugiura, A.: The possible origin of H3N2 influenza virus. Virology 120, 504–509 (1982).
Nakamura, K., Kitame, F., Homma, M.: A comparison of proteins among various influenza B virus strains by one-dimensional pepdde mapping. J. Gen. Virol. 56, 315–323 (1981).
Nerome, K., Ishida, M., Kakayama, M., Oya, A., Kanai, C., Suwicha, K.: Antigenic and genetic analysis of A/Hong Kong (H3N2) influenza viruses isolated from swine and man. J. Gen. Virol. 56,441–445 (1981).
Ortin, J., Najera, R., Lopez, C., Davila, M., Domingo, E.: Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome. Gene 11,319–331 (1980).
Oxford, J. S., Corcoran, T., Schild, G. C.: Intratypic electrophoretic variation of structural and nonstructural polypeptides of human influenza A viruses. J. Gen. Virol. 56, 431–436 (1981).
Palese, P.: The genes of influenza virus. Cell 10, 1–10 (1977).
Palese, P., Schulman, J. L.: Mapping of the influenza virus genome: Identification of the hemagglutinin and the neuraminidase genes. Proc. Natl. Acad. Sci. U.S.A. 73, 2142–2146 (1976).
Palese, P., Ritchey, M. B., Schulman, J. L.: Mapping of the influenza virus genome. II. Identification of the PI, P2, and P3 genes. Virology 76, 114–121 (1977 a).
Palese, P., Ritchey, M.B.: Polyacrylamide gel electrophoresis of the RNA of new influenza virus strains: An epidemiological tool. (Int. Symp. Influenza Immunization, 2nd, 1977.) Dev. Biol. Stand. 39, 411–415 (1977 b).
Palese, P., Racaniello, V. R., Desselberger, U., Young, J., Baez, M.: Genetic structure and genetic variation of influenza viruses. Phil. Trans. R. Soc. (Lond.) B288, 299–305 (1980).
Palese, P., Elliott, R. M., Baez, M., Zazra, J. J., Young, J. F.: Genome diversity among influenza A, B, and C viruses and genetic structure of RNA 7 and RNA 8 of influenza A viruses. In: Genetic Variation among Influenza Viruses (Nayak, D.P., ed.) (ICN-UCLA Symposia on Molecular and Cellular Biology. Vol. XXI), 127–140. New York-London-Toronto-Sydney-San Francisco: Academic Press 1981.
Porter, A. G., Barber, C., Carey, N. H., Hallewell, R. A., Threlfall, G., Emtage, J. S.: Complete nucleotide sequence of an influenza virus hemagglutinin gene from cloned DNA. Nature 282,471–477 (1979).
Porter, A. G., Smith, J. C., Emtage, J. S.: Nucleotide sequence of influenza virus RNA segment 8 indicates that coding regions for NSI and NS2 proteins overlap. Proc. Natl. Acad. Sci. U.S.A. 77, 5074–5078 (1980).
Ritchey, M. B., Palese, P., Schulman, J. L.: Mapping of the influenza virus genome. III. Identification of genes coding for nucleoproteins, membrane protein, and nonstmctural protein. J. Virol. 20, 307–313 (1976).
Robertson, J. S.: 5’ and 3’ terminal nucleotide sequences of the RNA genome segments of influenza virus. Nucl. Acids Res. 6, 3745–3757 (1979).
Rohde, W., Harms, E., Scholtissek, C.: Biochemical studies on influenza viruses. 1. Comparative analysis of equine 2 virus and virus N genes and gene products. Virology 79, 393–404 (1977).
Rose, J. K., Gallione, C.J.: Nucleotide sequences of the NA’s encoding the vesicular stomatitis virus G and M proteins determined from NA clones containing the complete coding regions. J. Virol. 39, 519–528 (1981).
Sanger, F., Nicklen, S., Coulson, A. R.: DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Scholtissek, C.: Synthesis in vitro of RNA complementary to parental viral RNA by RNA polymerase induced by influenza virus. Biochim. Biophys. Acta 179, 389–397 (1969).
Scholtissek, C.: The genome of the influenza virus. Curr. Top. Microbiol. Immunol. 80, 139–169 (1978).
Scholtissek, C.: Influenza virus genetics. Adv. Genetics 20, 1–36 (1979 a).
Scholtissek, C.: The genes coding for the surface glycoproteins of influenza A viruses contain a small conserved and a large variable region. Virology 93, 594–597 (1979 b).
Scholtissek, C.: The Structure of the hemagglutinin and neuraminidase genes as revealed by molecular hybridization. In: Structure and Variation in Influenza Virus (Laver, G., Air, G., eds.), 191–199. New York-Amsterdam-Oxford: Elsevier/North-Holland 1980.
Scholtissek, C., Rott, R.: Behavior of virus-specific activities in tissue cultures infected with myxoviruses after chemical changes of the viral ribonucleic acid. Virology 22, 169–176 (1964).
Scholtissek, C., Rott, R.: Hybridization studies with influenza virus RNA. Virology 39, 400–407 (1969).
Scholtissek, C., Rott, R.: Synthesis in vivo of influenza virus plus and minus strand RNA and its preferential inhibition by antibiotics. Virology 40, 989–996 (1970).
Scholtissek, C., von Hoyningen-Huene, V.: Genetic relatedness of the gene which codes for the nonstructural (NS) protein of different influenza A strains. Virology 102, 13–20 (1980).
Scholtissek, C., Harms, E., Rohde, W., Orlich, M., Rott, R.: Correlation between RNA fragments of fowl plague virus and their corresponding gene functions. Virology 74, 332–344 (1976).
Scholtissek, C., Rohde, W., Harms, E., Rott, R.: Correlation between the base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses. Virology 79,330–336 (1977 a).
Scholtissek, C., Rohde, W., Harms, E.: Genetic relationship between an influenza A and B virus. J. Gen. Virol. 37, 243–247 (1977 b).
Scholtissek, C., Rohde, W., von Hoyningen, V., Rott, R.: On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology 87, 13–20 (1978 a).
Scholtissek, C., von Hoyningen, V., Rott, R.: Genetic relatedness between the new 1977 epidemic strains (Hl) of influenza and human influenza strains isolated between 1947 and 1957 (Hl). Virology 89, 613–617 (1978 b).
Scholtissek, C., Rott, R., Lvov, D. K., Myasnikova, I. A.: Genetic relatedness of the neuraminidase of influenza A strains Nav2, Nav3, and Nav6. Arch. Virol. 65, 325–328 (1980).
Skehel, J.J., Waterfield, M.D.: Studies on the primary structure of influenza virus hemagglutinin: Proc. Natl. Acad. Sci. U.S.A. 72, 93–97 (1975).
Skehel, J.J., Hay, A. J.: Nucleotide sequences at the 5’ termini of influenza virus RNAs and their transcripts. Nucl. Acids Res. 5,1207–1219 (1978).
Skehel, J. J., Waterfield, M. D., Mauley, J. W., Elder, K., Wiley, D. C.: Studies on the Structure of the hemagglutinin. Phil. Trans. R. Soc. (Lond.) B288, 335–339 (1980).
Sleigh, M. J., Both, G. W., Underwood, P. A., Bender, V. J.: Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity. J. Virol. 37, 845–853 (1981).
Sriram, G., Bean, W.J., Hinshaw, V. S., Webster, R. G.: Genetic diversity among avian influenza viruses. Virology 105, 592–599 (1980).
Van Rompuy, L., Min Jou, W., Huylebroeck, D., Devos, R., Fiers, W.: Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HONl). Eur. J. Biochem. 116, 347–353 (1981). Corrections: Eur. J. Biochem. 126, 645 (1982).
Verhoeyen, M., Fang, R., Min Jou, W., Devos, R., Huylebroeck, D., Saman, E., Fiers, W.: Antigenic drift between the hemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75. Nature 286, 771–776 (1980).
Ward, C.W., Dopheide, T. A.A.: A Hong Kong influenza hemagglutinin light chain: Amino acid sequence of cyanogen bromide fragment CN2. Virology 95, 107–118 (1979).
Ward, C. W., Dopheide, T. A.: The Hong Kong (H3) hemagglutinin. Complete amino acid sequence and oligosaccharide distribution for the heavy chain of A/Memphis/102/72. In: Structure and Variation in Influenza Virus (Laver, G., Air, G., eds.), 27–38. New York-Amsterdam-Oxford: Elsevier/North-Holland 1980.
Ward, C. W., Webster, R. G., Inglis, A. S., Dopheide, T. A.: Composition and sequence studies show that A/duck/Ukraine/1/63 hemagglutinin (Hav7) belongs to the Hong Kong (H3) subtype. J. Gen. Virol. 53,163–168 (1981).
Waterfield, M.D., Skehel, J.J., Nakashima, Y., Gurnett, A., Bilham, T.: Stmctural studies of the hemagglutinin of the Asian influenza vimapan/305/57-Bellamy/42 (H2N1). Cyanogen bromide cleavage of the larger polypeptide chain HAl. In: Topics in Infectious Diseases, Vol. 3: The Influenza Virus Hemagglutinin (Laver, W. G., Bachmayer, H., Weil, R., eds.), 167–179. Wien-New York: Springer 1978.
Webster, R. G., Hinshaw, V. S., Bean, W. J., Van Wyke, K. L., Geraci, J. R., St. Aubin, D. J., Petursson, G.: Characterization of an influenza A virus from seals. Virology 113, 712–724 (1981).
Webster, R. G., Laver, W. G., Air, G. M., Schild, G. C.: Molecular mechanisms ofvariation in influenza viruses. Nature 296, 115–121 (1982).
WHO-Bulletin (1979). Reconsideration of influenza A virus nomenclature: a WHO Memorandum. Bull. World Health Org. 57, 227–233 (1979).
WHO-Bulletin (1980). A revision of the system of nomenclature for influenza viruses: a WHO Memorandum. Bull. World Health Org. 58, 585–591 (1980).
Wiley, D. C., Wilson, I. A., Skehel, J. J.: Structural identification of the antibody-binding site oong Kong influenza hemagglutinin and their involvement in antigenic variation. Nature 289,373–378 (1981).
Wilson, LA., Skehel, J. J., Wiley, D.C.: Structure of the hemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289, 366–373 (1981).
Winter, G., Fields, S.: Cloning of influenza NA into M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucl. Acids Res. 8, 1965–1974 (1980).
Winter, G., Fields, S.: The structure of the gene encoding the nucleoprotein of human influenza virus A/PR/8/34. Virology 114, 423–428 (1981).
Winter, G., Fields, S.: Nucleotide sequence of human influenza A/PR/8/34 segment 2. Nucl. Acids Res. 10, 2135–2143 (1982).
Winter, G., Fields, S., Gait, M. J., Brownlee, G. G.: The use of synthetic oligodeoxynucleotide primers in cloning and sequencing segment 8 of influenza virus (A/PR/8/34). Nucl. Acids Res. 9,237–245 (1981 a).
Winter, G., Fields, S., Brownlee, G. G.: Nucleotide sequence of the hemagglutinin gene of a human influenza virus HI subtype. Nature 292, 72–75 (1981 b).
Young, J. F., Palese, P.: Evolution of human influenza A viruses in nature: Recombination contributes to genetic variation of Hl strains. Proc. Natl. Acad. Sci. U.S.A. 76, 6547–6551 (1979).
Young, J. F., Desselberger, U., Palese, P.: Evolution of human influenza A viruses in nature: Sequential mutations in the genomes of new Hl isolates. Cell 18, 73–83 (1979).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag/Wien
About this chapter
Cite this chapter
Scholtissek, C. (1983). Genetic Relatedness of Influenza Viruses (RNA and Protein). In: Palese, P., Kingsbury, D.W. (eds) Genetics of Influenza Viruses. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8706-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8706-7_4
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8708-1
Online ISBN: 978-3-7091-8706-7
eBook Packages: Springer Book Archive