The Influenza Virus RNA Segments and Their Encoded Proteins

  • R. A. Lamb


In this chapter the structure of the genes of influenza virus and their encoded proteins will be described. Influenza viruses contain a segmented single-stranded RNA genome which has been called “negative stranded” because the viral messenger RNAs are transcribed from the viral RNA segments. A great deal of new knowledge has been obtained about influenza A, B, and C viruses since the last major reviews of influenza virus in 1975 (Kilbourne, 1975). The complete sequence of the 8 RNA segments of influenza A virus has been obtained and this has led to a greatly increased understanding of the encoded polypeptides and how variation among influenza viruses occurs. A large body of evidence concerning changes in the surface glycoproteins, the hemagglutinin and neuraminidase, has been obtained from studies on the primary sequences, interactions with antibodies and the correlation of these data with the three-dimensional X-ray structure of these proteins.


Influenza Virus Complete Nucleotide Sequence Encode Protein cDNA Copy Human Influenza Virus 
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© Springer-Verlag/Wien 1983

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  • R. A. Lamb

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