Virus-Determined Differences in the Pathogenesis of Influenza Virus Infections

  • J. L. Schulman


Among the variations in phenotype expressed by different influenza viruses are differences in biological activity in various host cell systems, including differences in host range, organ specificity and dissemination in animals and plaquing efficiency in various cell culture systems. With the availability of reliable laboratory techniques to determine the parental origins of individual RNA segments in reassortant viruses obtained in nature or in the laboratory, it has become possible to obtain previously unavailable information concerning the contribution of individual genes or combinations of genes to some of these biological differences and to begin to address some fundamental questions regarding the molecular mechanisms involved.


Influenza Virus Mixed Infection Avian Influenza Virus Influenza Virus Infection MDBK Cell 
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  • J. L. Schulman

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