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Streptonigrin

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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Abstract

A collaborative effort between researchers at Chas. Pfizer, Inc. and at the Sloan-Kettering Institute led to the discovery that a filtrate from cultures of Streptomyces flocculus had significant anticancer and antibiotic activity. The active agent was eventually isolated, named streptonigrin, and shown to have the structure depicted in (1). During the last twenty years streptonigrin has been the subject of intensive study regarding its use as an anticancer drug, its cytotoxic mechanism of action, its laboratory synthesis, and its biosynthesis.

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Authors and Affiliations

  1. School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA

    St. J. Gould

  2. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA

    St. M. Weinreb

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  1. St. J. Gould
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Editors and Affiliations

  1. Department of Chemistry, The Florida State University, Tallahassee, Florida, USA

    W. Herz (Professor of Chemistry) (Professor of Chemistry)

  2. Biologisches Institut II, Lehrstuhl für Biochemie der Pflanzen, Albert-Ludwigs-Universität, Freiburg i. Br., Federal Republic of Germany

    H. Grisebach

  3. Chemistry Department, The University, Glasgow, Scotland

    G. W. Kirby Sc. D. (Regius Professor of Chemistry) (Regius Professor of Chemistry)

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Gould, S.J., Weinreb, S.M. (1982). Streptonigrin. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8656-5_3

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  • DOI: https://doi.org/10.1007/978-3-7091-8656-5_3

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