Analysis and Toxicological Safety Evaluation of Environmental Pollutants

  • Dietrich Henschler
Conference paper


Qualitative and quantitative changes in the exposure pattern of modern mankind to chemical, and the increasing awareness of new types of diseases caused by irreversible damages (mutagenesis, carcinogenesis, teratogenesis) have prompted a revision of safety testing strategies of drugs, and occupational and environmental chemicals. New elements of toxicological methodology are: pharmaco-kinetics, metabolism of xenobiotics, identification of toxic metabolites by examination of excretable and non-excretable reaction products with biomolecules, and short-term tests. Proper use of these elements in testing procedures decisively improves the prediction of toxic reactions in humans.


Vinyl Chloride Safety Evaluation Covalent Binding Toxic Reaction Mercapturic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Verband der Chemischen Industrie e.V., Frankfurt/M., personal communication by Dr. W. Munte 5/12/1980Google Scholar
  2. 2.
    MAK-Werte-Listen, Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, 1972–1980Google Scholar
  3. 3.
    J.S.P. Jones, F.D. Pooley, P.G. Smith: I.N.S.E.R.M. Symp. Ser. Vol. 52, 117, Paris 1976Google Scholar
  4. 4.
    G.H. Degen, H.-G. Neumann: 7thCongress IUPHAR, Abstr. No.1464, Paris 1978Google Scholar
  5. 5.
    P. Kleihues, G. Doerjer, J.A. Swenberg, E. Hanenstein, J. Bücheler, H.K. Cooper: Arch. Toxicol. Suppl. 2, 253 (1979)CrossRefGoogle Scholar
  6. 6.
    W.K. Lutz: Mutat. Res. 65, 289 (1979)Google Scholar
  7. 7.
    L. Ehrenberg, S. Osterman-Golkar, D. Segerbäck, K. Swenson, C.J. Calleman: Mutat. Res. 45, 175 (1977)CrossRefGoogle Scholar
  8. 8.
    H.-G. Neumann, H. Baur, R. Wirsing: Arch. Toxicol. Suppl. 3, 69 (1980)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1981

Authors and Affiliations

  • Dietrich Henschler
    • 1
  1. 1.Institute for Pharmacology and ToxicologyUniversity of WürzburgWürzburgFederal Republic of Germany

Personalised recommendations