Septal Stimulation on Painful and Symbolic Stress. Experimental Study

  • J. Broseta
  • J. L. Barcia-Salorio
  • J. Barberá
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 30)


Based on the rewarding effect of septal area, therapeutic Stimulation of this region has been applied to surgical management of chronic pain. However some basic problems of this technique remain unsolved. Thus the effect of septal Stimulation was tested on an experimental model of painful and symbolic stress, comparing the variations in the pituitaryadrenal axis activity, the peripheral cathecolamine levels and the structural changes in gastric mucosa and adrenal glands, between the problem and different control groups. The bioelectrical activity of septal area and antexolateral hypothalamus during Stimulation were recorded. A decrease in gastric ulceration and plasma cortisol were observed in the septal stimulation group. No direct influence on the cathecolaminic system was noted. A facilitation of septal activity and its influence on hypothalamic rythm were found. All these effects were mainly achieved in the posterior perifornical septal region.


Rewarding Effect Septal Area Septal Group Gastric Pathology Septal Stimulation 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • J. Broseta
    • 1
  • J. L. Barcia-Salorio
  • J. Barberá
  1. 1.Departamento de NeurocirugiaHospital Clínico UniversitarioValencia-10Spain

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