Quantitative Dissection of Human Brain Areas: Relevance to Transmitter Analyses

  • St. Wuketich
  • P. Riederer
  • K. Jellinger
  • L. Ambrozi
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 16)


Comparison of the fresh weights of whole brains and of five quantitatively dissected subcortical nuclei (caudate n., putamen, globus pallidus, amygdala, n. ruber) were performed between 11 cases of Parkinson’s disease (76.5 ±1.85 years), 4 cases of Huntington’s chorea (63.2 ±1.9 years) and 17 age-matched controls without neurological disorders (71.53 ±0.26 years). The fresh weights of these brain loci and the concentrations of dopamine (DA), norepinephrine (NE) and Serotonin (5-HT) in controls and parkinsonian brains were compared. The average weight of parkinsonian brain was 1136.2 ± 100.1 g and was 1181.6 ± 154.8 g for controls, with no difference in the weights of the lenticular nuclei between these two groups, while in Huntington’s chorea there was significant reduction of the whole brain weight (84.3% of controls) and of the caudate n. and putamen (47.4 and 43.3%). The gl. pallidus was less severely reduced in Huntington’s chorea (73.2 °/o), while the weights of the amygdala and n. ruber were similar for the three groups. Comparison of the absolute and relative concentrations of monoamines in the 5 dissected nuclei was performed.


Caudate Nucleus Globus Pallidus Brain Atrophy Brain Weight Parkinsonian Patient 
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • St. Wuketich
    • 1
    • 2
  • P. Riederer
    • 1
    • 2
    • 3
  • K. Jellinger
    • 1
    • 2
  • L. Ambrozi
    • 1
    • 2
  1. 1.Department of PathologyLainz-HospitalWienAustria
  2. 2.Ludwig Boltzmann-Institute of Clinical NeurobiologyLainz-HospitalWienAustria
  3. 3.Ludwig Boltzmann-Institute of Clinical NeurobiologyLainz-HospitalWienAustria

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