Unilateral Parkinson’s Disease and Contralateral Tardive Dyskinesia: A Unique Case with Successful Therapy That May Explain the Pathophysiology of These Two Disorders

  • S. Fahn
  • R. Mayeux
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 16)


A unique case is reported of a patient with right-sided Parkinson’s disease and left-sided tardive dyskinesia. This Situation occurred because the patient’s parkinsonian tremor was treated with antipsychotic drugs. After several months she developed tardive dyskinesia on the left side of the body. Successful treatment was achieved nine years later, using dopaminedepleting drugs (combination reserpine and alpha-methylparatyrosine) to suppress the tardive dyskinesia and trihexyphenidyl to reduce the parkinsonism. Control of the symptoms was complicated when parkinsonism symptoms later increased on the right and developed on the left, due to the dopamine-depleting drugs. A small amount of carbidopa/levodopa restored the proper balance of symptoms, effectively reducing the parkinsonism while not aggravating the tardive dyskinesia.

This unique case provides insight into the pathogenesis of Parkinson’s disease, the pathogenesis of tardive dyskinesia, their successful therapeutic approaches, and possibly the effect of drugs in blocking the progression of Parkinson’s disease.


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • S. Fahn
    • 1
    • 2
  • R. Mayeux
    • 1
  1. 1.Department of Neurology, College of Physicians and SurgeonsColumbia University, and The Neurological Institute of New YorkNew YorkUSA
  2. 2.Department of Neurology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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