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Dopamine Oxidation and Its Inhibition by (—)-Deprenyl in Man

  • Vivette Glover
  • J. D. Elsworth
  • M. Sandler
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 16)

Summary

Dopamine is predominantly oxidized by a (-)-deprenyl sensitive form of MAO in the human striatum, and (-)-deprenyl, acting at some suitably low selective inhibitory concentration may, therefore, be of benefit in Parkinson’s disease. 10-6M was the most effective (-)-deprenyl concentration in vitro for discriminating between the inhibition of MAO A and B. The correlation between the A/B ratio present in different human brain regions and the sensitivity of dopamine oxidation to 10-6M deprenyl was 0.84 (p < 0.001). This suggests that all dopamine oxidation can be accounted for by the joint contribution of MAO A and B and that it is unnecessary to postulate a special form of the enzyme which metabolizes dopamine. In the brain, the striatum has the highest proportion of MAO B, and in several cortical regions, relatively more dopamine is oxidized by MAO A. In other human tissues also the deprenyl sensitivity of dopamine oxidation correlated with the known A/B ratio, the placenta, lung and jejeunum having the lowest sensitivity and being the richest in MAO A. Km values for dopamine for MAO A and B are similar, 130 and 140 μM respectively, so that the proportion oxidized by the two forms should not vary with substrate concentration.

Keywords

Monoamine Oxidase Phenyl Ethanolamine Dopamine Oxidation Human Striatum Human Brain Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Vivette Glover
    • 1
  • J. D. Elsworth
    • 1
  • M. Sandler
    • 1
    • 2
  1. 1.Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and GynaecologyQueen Charlotte’s Maternity HospitalLondonUK
  2. 2.Bernhard Baron Memorial Research LaboratoriesQueen Charlotte’s Maternity HospitalLondonUK

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