Several lines of evidence suggest an association between RNA tumor viruses and cancer in man (Gillespie, Saxinger and Gallo, 1975; Viola et al., 1976; Gallo and Gillespie, 1977). If the link is a causal one, the availability of the causative agent could be useful both for research and for therapy. The rare isolation of infectious type-C RNA viruses from cultured human tissues has been reported by several groups (see later). These reports have generated criticisms of two major forms: (1) If type-C RNA viruses cause human cancer, they should be regularly isolated from the neoplastic tissue and (2) the viruses could be contaminants which were inadvertently introduced into the tissue sample during the course of laboratory manipulation.
KeywordsInfectious Virus Rous Sarcoma Virus Reverse Transcriptase Activity Molecular Hybridization Uninfected Target Cell
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