The Transposition of Ampicillin Resistance: Nature of Ampicillin Resistant Haemophilus influenzae and Neisseria gonorrhoeae
Transposable elements are discrete genetic and physical entities which can move from one replicon to another. This event occurs in recombination-deficient (recA−) bacteria where homologous recombination has been eliminated by mutation. Transposable elements include the IS insertion sequences (see P. Starlinger, this volume; H. Seadler, this volume) and transposable antibiotic resistance genes (see P. Bennett, this volume; J. Davies, this volume). In this paper, we shall be concerned with the transposable sequence which includes the determinants for β-lactamase production, the so-called TnA element. The designation TnA is a general term for several independently described transposition elements that carry ampicillin resistance (Apr). At least three distinct elements are known which have been designated Tnl, Tn2 and Tn3; presumably others will be described in future. Most of our discussion concerns the Tn2 transposable element, although it seems fair to assert that all of the transposable ampicillin elements described, thus far, are closely related and possess similar genetic and physical properties.
KeywordsTransposable Element Haemophilus Influenzae Neisseria Gonorrhoeae Shigella Dysenteriae Enteric Species
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