The Molecular Nature of R-Factors in Different Bacterial Hosts

  • G. O. Humphreys
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 2)


Genetic and molecular studies of R-factors have led to the definition of two classes of plasmid transfer systems (3,4,19,23,36,40). The resistance (and/or colicin) determinant(s) and transfer factor of Class 1 transfer systems are covalently linked, and are transferred to new hosts as a single linkage group. The R-factor T-Δ2 and the colicinogenic factor ColIb-P9 are examples of Class 1 transfer systems (2,3,23). In Class 2 systems, the transfer factor and non-autotransferring resistance (or colicin) determinant(s) are independent replicons, which can be transferred separately to recipient cells, and which rarely recombine. The resistance determinant SSu and transfer factor Δ form a Class 2 transfer system (2,3,23).


Transfer Factor Proteus Mirabilis Resistance Determinant Tetracycline Resistance Compatibility Group 
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© Springer-Verlag/Wien 1977

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  • G. O. Humphreys

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