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Plasmid-Mediated Tetracycline Resistance in E. coli

  • Conference paper
R-Factors: Their Properties and Possible Control

Part of the book series: Topics in Infectious Diseases ((TIDIS,volume 2))

Abstract

The tetracyclines are effective bacteriostatic drugs for a wide variety of microbial infections. They inhibit the binding of aminoacyl transfer RNA to the 30S ribosomal subunit (1). More specifically they appear to interfere with the codon-anticodon interaction (2). The drug has worldwide usage therapeutically as well as prophylactically in humans, domestic and farm animals, and plants. It is, therefore, not surprising that the emergence of resistance to this drug has also occurred worldwide and in epidemic proportions. In fact, in most organisms tested, if resistances to antibiotics have been found, tetracycline resistance is among them. The list includes all Enterobacteriaceae, Pseudomonas, Hemophilus influenza, Streptococcus fecalis, Clostridia perfringins and Staphylococcus aureus (3,4). The most common mode of resistance is by plasmids on which are found the genes for resistance. A clear understanding of the mechanism of resistance in these different species has not yet been reached. Some information has been obtained, however, in studies of Enterobacteriaceae (5,6,7) and Staphylococcus aureus (8,9). In most Enterobacteriaceae studied and in Staphylococcus expression of resistance is regulated (6,7,9). We have identified a tetracycline-inducible protein, TET, associated with tetracycline resistance (7,10) in E. coli and we have partially purified a “repressor” which regulates synthesis of this protein (11). Our results suggest that, as is TET protein, so is the whole tetracycline resistance operon under negative control releasable by tetracycline.

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Authors
  1. Stuart B. Levy
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  2. Laura McMurry
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  3. Philip Onigman
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  4. Richard M. Saunders
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Editor information

Editors and Affiliations

  1. Section of Chemotherapy, Sandoz Forschungsinstitut Gesellschaft m. b. H., Brunnerstrasse 59, A-1235, Vienna, Austria

    Jürgen Drews (Head) (Head)

  2. Department of Experimental Chemotherapy, Sandoz Forschungsinstitut Ges. m. b. H., Brunnerstrasse 59, A-1235, Vienna, Austria

    Gregor Högenauer

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© 1977 Springer-Verlag/Wien

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Levy, S.B., McMurry, L., Onigman, P., Saunders, R.M. (1977). Plasmid-Mediated Tetracycline Resistance in E. coli. In: Drews, J., Högenauer, G. (eds) R-Factors: Their Properties and Possible Control. Topics in Infectious Diseases, vol 2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8501-8_12

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  • DOI: https://doi.org/10.1007/978-3-7091-8501-8_12

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8503-2

  • Online ISBN: 978-3-7091-8501-8

  • eBook Packages: Springer Book Archive

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