Evolutional Process of the Formation of Multiple Resistance Plasmids

  • S. Mitsuhashi
  • H. Kawabe
  • T. Nagate
  • K. Inoue
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 2)


Sulfanilamide(SA) and its derivatives were used in Japan since 1940 against infections with both gram-positive and gram-negative bacteria and pioneered a chemotherapy as an effective antibacterial agent. In parallel with the wide use of the drugs, the isolation frequencies of SA-resistant strains of bacteria increased and reached a maximum of 90–95% of Shigella and Staphylococcus aureus isolates being resistant to SA(1–4).


Coli Strain Amino Glycoside Antibiotic Isolation Frequency Demonstration Frequency Conjugative Plasmid 
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© Springer-Verlag/Wien 1977

Authors and Affiliations

  • S. Mitsuhashi
  • H. Kawabe
  • T. Nagate
  • K. Inoue

There are no affiliations available

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