The Coding of Small RNA Molecules by the Resistance Factor R 1

  • Gregor Högenauer
  • Gabriella Hartmann
  • Christine Ruf
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 2)


The genetic and evolutionary origin of the resistance determinants of R-factors is unknown. The genes which code for the synthesis of resistance functions are expressed in different bacterial hosts at high levels. This could mean that the transcriptional and translational machinery of bacterial species is a priori capable of efficiently expressing genes which may have evolved in other organisms. Alternatively, the rate at which the foreign genes are expressed in bacteria may depend on the complementation of the chromosomally coded protein synthesis system of the host with components coded for by the R-factor. One type of molecule that may have to be supplied by the R-factor in order to promote optimal translation of its genes might be tRNA because the tRNA composition is in a given species probably related to the overall spectrum of DNA code words.


Filter Disc tRNA Molecule Optical Density Profile Fraction Number Figure DEAE Column Chromatography 
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Copyright information

© Springer-Verlag/Wien 1977

Authors and Affiliations

  • Gregor Högenauer
  • Gabriella Hartmann
  • Christine Ruf

There are no affiliations available

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