Abstract
The genetic and evolutionary origin of the resistance determinants of R-factors is unknown. The genes which code for the synthesis of resistance functions are expressed in different bacterial hosts at high levels. This could mean that the transcriptional and translational machinery of bacterial species is a priori capable of efficiently expressing genes which may have evolved in other organisms. Alternatively, the rate at which the foreign genes are expressed in bacteria may depend on the complementation of the chromosomally coded protein synthesis system of the host with components coded for by the R-factor. One type of molecule that may have to be supplied by the R-factor in order to promote optimal translation of its genes might be tRNA because the tRNA composition is in a given species probably related to the overall spectrum of DNA code words.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gillespie, S., and Gillespie, D.: Ribonucleic Acid-Deoxyribonucleic Acid Hybridization in Aqueous Solutions and in Solutions Containing Formamide. Biochem. J. 125, 481–487 (1971).
Marmur, J.: Isolation and Characterisation of Low Molecular Weight Ribonucleic Acid Species From Bacillus subtilis. J. Mol. Biol. 3, 208–218 (1962).
Landy, A., Abelson, J., Goodman, H.M., and Smith, J.D.: Specific Hybridization of Tyrosine Transfer Ribonucleic Acids With DNA From a Transducing Bacteriophage 0 80 Carrying the Amber Suppressor Gene SMIII. J. Mol. Biol. 29, 457–471 (1967).
Loening, U.E.: The Fractionation of High-Molecular-WeightRibonucleic Acid by Polyacrylamide-Gel Electrophoresis. Biochem. J. 102, 251–257 (1967).
Clewell, D.B., and Helinski, D.R.: Supercoiled Circular DNA-Protein Complex in Escherichia coli: Purification and Induced Conversion to an Open Circular DNA Form. Proc. Natl. Acad. Sci. USA 62, 1159–1166 (1969).
Jakovic, S., Casey, J., and Rabinowitz, M.: Sequence Homology of the Mitochondrial Leucyl tRNA Cistron in Different Organisms. Biochemistry 14, 2037–2042 (1975).
Meijs, W.H., and Schiperoort, R.A.: Determination of the Amount of DNA on Nitrocellulose Membrane Filters. FEBS Letters 12, 166–168 (1971).
Weiss, S.B., Hsu, Wen-Tah, Foft, J.W., and Scherberg, H.: Transfer RNA Coded by the T4 Bacteriophage Genome. Proc. Natl. Acad. Sci. USA 61, 114–121 (1968).
Nygaard, A.P., and Hall, B.D.: Formation and Properties of RNA-DNA Complexes. J. Mol. Biol. 9, 125–142 (1964).
Morris, C.F., Hashimoto, H., Mickel, S., and Rownd, R.: Round of Replication Mutant of a Drug Resistance Factor. J. Bact. 118, 855–866 (1974).
Pearson, R.L., Weiss, J.F., and Kelmers, A.D.: Improved Separation of Transfer RNAs on Polychlorotrifluoroethylenesupported Reversed-phase Chromatography Columns. Biochem. Biophys. Acta 228, 770–774 (1971).
Singer, C.E., Smith, G.R., Cortese, R., and Ames, B.N.: Mutant tRNAHis Ineffective in Repression and Lacking Two Pseudouridine Modifications. Nature New Biol. 238, 72–74 (1972).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag/Wien
About this paper
Cite this paper
Högenauer, G., Hartmann, G., Ruf, C. (1977). The Coding of Small RNA Molecules by the Resistance Factor R 1. In: Drews, J., Högenauer, G. (eds) R-Factors: Their Properties and Possible Control. Topics in Infectious Diseases, vol 2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8501-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8501-8_10
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8503-2
Online ISBN: 978-3-7091-8501-8
eBook Packages: Springer Book Archive