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Advances in Stereotactic and Functional Neurosurgery 2 pp 191–198Cite as

The Effects of Drugs on the Field Potential in the Caudate Nucleus Following Nigra Stimulation

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Part of the book series: Acta Neurochirurgica Supplementum ((STEREOTACTIC,volume 24))

Abstract

The reciprocal connections of the caudate (Cd) and nigra (Ni) nuclei have been extensively studied using anatomical 2, 17, 26, 27, 28, 35, 36, 37, histochemical 1, 13, 30, 8 and electrophysiological 3, 6, 9, 12, 14, 15, 22, 23, 24. 38 methods but in some respects the situation is even less satisfactory than a few years ago. The present communication is aimed at examining the characteristics of field potentials in the Cd evoked from stimulation of the Ni before and after systemic application of drugs. The cats were anaesthetized with sodium pentobarbital (30–40 mg/kg), immobilized by flaxedil and artifically ventilated. The overlying cortical structures were removed by suction to expose the dorsal surface of the Cd. The nigro-caudate pathway was electrically stimulated using bipolar electrodes placed in the Ni proper. Similar electrodes in the cerebral peduncle (CP) allowed antidromic activation of the Cd. Field potentials were recorded in the medial two thirds of the ipsilateral Cd with glass microelectrodes filled with either 2 M sodium chloride or 3 M potassium chloride (DC resistance: 3–5 MΩ). A Nicollete 1074 was used for averaging the signals. The recording and stimulating electrode tracts were identified histologically.

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Author information

Authors and Affiliations

  1. Department of Neurobiology, Max-Planck-Institut für Hirnforschung, Frankfurt/M., Federal Republic of Germany

    Dr. A. Wagner, M. Dupelj & K. C. Lee

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  1. Dr. A. Wagner
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  2. M. Dupelj
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  3. K. C. Lee
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Editor information

Editors and Affiliations

  1. Western General Hospital, University of Edinburgh, Edinburgh, UK

    F. John Gillingham (Professor of Neurosurgery) & Edward R. Hitchcock (Consultant Neurosurgeon) (Professor of Neurosurgery) &  (Consultant Neurosurgeon)

  2. Royal Infirmary, University of Edinburgh, Edinburgh, UK

    F. John Gillingham (Professor of Neurosurgery) & Edward R. Hitchcock (Consultant Neurosurgeon) (Professor of Neurosurgery) &  (Consultant Neurosurgeon)

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© 1977 Springer-Verlag

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Wagner, A., Dupelj, M., Lee, K.C. (1977). The Effects of Drugs on the Field Potential in the Caudate Nucleus Following Nigra Stimulation. In: Gillingham, F.J., Hitchcock, E.R. (eds) Advances in Stereotactic and Functional Neurosurgery 2. Acta Neurochirurgica Supplementum, vol 24. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8482-0_26

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  • DOI: https://doi.org/10.1007/978-3-7091-8482-0_26

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-81422-2

  • Online ISBN: 978-3-7091-8482-0

  • eBook Packages: Springer Book Archive

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