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Structural, Ultrastructural and Functional Reactions of the Brain After Implanting Yttrium 90 Rods Used in Stereotactic Neurosurgery

  • E. Csanda
  • F. Joó
  • I. Somogyi
  • A. Szücs
  • M. Saal
  • A. Auguszt
  • S. Komoly
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 24)

Abstract

In stereotactic neurosurgery the implantation of beta irradiating Y 90 rods for producing circumscribed lesions in the brain has been successfully used for a long time, as for instance in the impressive series of frontal psychochirurgical lesions done by Dr. Knight. Dr. Talairach’s team in Paris used the same type of radioactive lesionmaking. Whilst lesions in the gray matter appeared to be regular and satisfactory from the clinical and histological point of view, after more extensive lesions of the white matter of the hemispheres some side effects appeared, consisting mainly in more or less marked phenomena of brain oedema in about 20%. In 1970 with Szikla and Vedrenne 1, 2 we gave a first account of the histological alterations of the brain tissue provoked by focal irradiation. Later we extended these examinations on animal experiments and completed it with analysing the permeability changes 3, 4, 5.

Keywords

Evans Blue Histological Alteration Deep White Matter Functional Reaction Perifocal Oedema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vedrenne, Cl, Csanda, E., Fontaine, Ch., Szikla, G. (1970), Analyse histologique des lésions précoces et tardives par l’implantation intracérébrale chez l’homme d’un isotope emetterur bete: l’yttrium 90. Comptes rendus du VIe Congrés Internat, de Neuropathol, pp. 275–276. Paris: Masson.Google Scholar
  2. 2.
    Csanda, E., Szikla, G., Vedrenne, Cl. (1970), Étude expérimentale des modifications de la barrière hémo-encephalique sous l’effet du rayonnement beta. Comptes rendus du VIe Congrés Internat, de Neuropathol., pp. 271–272. Paris: Masson.Google Scholar
  3. 3.
    Csanda, E., Szücs, A., Dobranovics, I. (1972), Tierexperimentelle Beiträge zu dem durch einen Beta-Strahler (Yttrium 90) verursachten Hirnödem. 2. Donausymposion für Neuropathologie. Wiener klin. Wschr. 84, 435.Google Scholar
  4. 4.
    Csanda, E., Szücs, A., Dobranovics, I., Saal, M., Oswald, A. (1974), Hirn-schädigungen infolge von Beta-Strahler Yttrium 90. Weitere Untersudiungen zur Frage der prälymphatisch-lymphatischen Drainagebahn aus der Hirnsub-stanz. Folia Angiologica 22, 172–174.Google Scholar
  5. 5.
    Csanda, E., Szücs, A., Joó, F., Dobranovics, I., Saal, M., Oswald, A. (1974), Experimental data to the alterations of the central nervous system following beta irradiation. Proc. of the VIIe Internat. Congr. of Neuropathol. Budapest, 1974, pp. 765–768.Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • E. Csanda
    • 1
  • F. Joó
    • 1
  • I. Somogyi
    • 1
  • A. Szücs
    • 1
  • M. Saal
    • 1
  • A. Auguszt
    • 1
  • S. Komoly
    • 1
  1. 1.Institute of NeurologySemmelweis Medical UniversityBudapestHungary

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