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Experiences with Pharmacological Methods for the Lateralization of Temporal Epileptic Foci

  • N. A. Bercel
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 23)

Abstract

Of 96 temporal lobe epileptics treated since 1950, only 55% responded favorably to medication (before carbamazepine). Of the rest, 75% had bilateral temporal spikes (independent or synchronous), 23% had unilateral spikes and 2% had a normal record, wake and sleep. Since the bilateral spike cases respond most poorly to medication, they would need most a new approach, such as surgery, to rehabilitate them. However, they are not doing as well after temporal lobectomy when compared to those who had unilateral spikes. Falconer 1 (1963) found the operation successful in only one out of ten bitemporal cases while two out of three of his unilateral spike patients did well. He concluded that it is best to exclude from surgical consideration all cases of bilateral temporal spikes approaching a 50/50 parity. The idea of bitemporal lobectomy including the hippocampus is generally discarded because of its predictable catastrophic effect on recent memory.

Keywords

Temporal Lobe Epilepsy Fast Activity Temporal Lobectomy Slow Spreading Seizure Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Falconer, M. A., Serafetidines, E. A. (1963), A follow-up study of surgery in temporal lobe epilepsy. J. Neurol. Neurosurg. Psychiat. 26, 154–165.PubMedCrossRefGoogle Scholar
  2. 2.
    Crandall, P. A. (1975), Postoperative management and criteria for evaluation. Advances in Neurology, Vol. 8, pp. 265–279. New York: Raven Press.Google Scholar
  3. 3.
    Bailey, P., Green, J. R., Amador, L., Gibbs, F. A. (1953), Treatment of psychomotor states by anterior temporal lobectomy. (Chapter 29 in “Psychiatric Treatment”, 341–346.)Google Scholar
  4. 4.
    Walter, R. D. (1973), Tactical considerations leading to surgical treatment of limbic epilepsy. Epilepsy, its phenomena in man. Academic Press Inc., pp. 99–119.Google Scholar
  5. 5.
    Gloor, P., Rasmussen, T., Garretson, J. A. N. (1964), Fractionized intracarotid metrazol injection. Electroenceph. Clin. Neurophysiol. 17, 322–327.CrossRefGoogle Scholar
  6. 6.
    Gibbs, F. A., Amador, L., Rich, C. (1958), Electroencephalographic findings and therapeutic results in surgical treatment of psychomotor epilepsy. In: Temporal lobe epilepsy ( Baldwin, M., and Bailey, P., eds.), p. 364. Springfield, Ill.: Ch. C Thomas.Google Scholar
  7. 7.
    Ajmone-Marsan, C., Baldwin, M. (1958), Electrocorticography. In: Temporal lobe epilepsy ( Baldwin, M., and Bailey, P., eds.), pp. 368–395. Springfield, Ill.: Ch. C Thomas.Google Scholar
  8. Ziskind, E., Bercel, N. A. (1946), Studies in convulsive thresholds in epileptics and non-epileptics. Tr. Amer. Neurol. Assoc. 1946.Google Scholar
  9. 9.
    Brazier, M. A. B., Finesinger, J. E. (1945), Action of barbiturates on the cerebral cortex. EEG study. Arch. Neurol. Psychiat. (Chicago) 53, 51–58.Google Scholar
  10. 10.
    Schneider, J., Thomalske, G. (1956), L’éxploration pharmacodynamique cortico-sous-corticale et ses critères électrographiques. Electroenceph. Clin. Neurophysiol. 8, 353–369.Google Scholar
  11. 11.
    Pampiglione, G. (1952), Induced fast-activity in the EEG as an aid in the location of cerebral lesions. Electroenceph. Clin. Neurophysiol. 4, 79–82.Google Scholar
  12. 12.
    Lombroso, C., Erba, G. (1970), Primary and secondary bilateral synchrony in epilepsy. Arch. Neurol. 22, 321–334.PubMedCrossRefGoogle Scholar
  13. 13.
    Greenblatt, D. J. (1974), Slow absorption of intramuscular chloridiazepoxide. N. Engl. J. Med. 291, 116–118.Google Scholar
  14. 14.
    Roger, A. R. (1955), Contribution à l’étude expérimentale de l’épilepsie partielle. Thèse de Marseille. Laval, Impr. Barneoud, 60 pp.Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • N. A. Bercel
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Los AngelesUSA

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