Catecholamine Levels in Penicillin-Induced Epileptic Focus of the Cat Cerebral Cortex
Chen et al. (1954) first reported that pretreatment with reserpine lowered the threshold of experimental seizures. Since then the relationship between brain monoamines and susceptibility to epileptic seizures has been studied by many investigators by means of electroconvulsion (De Schaepdryver et al. 1962, Azzaro et al. 1972, Kilian and Frey 1973), pentylenetetrazol (Kobinger 1958, Lessin and Parkes 1959) and audiogenic seizures (Lehmann 1967, Boggan and Seiden 1971, Jobe et al. 1973). From the results of this work, it has been suggested that treatment lowering the total brain levels of monoamines generally facilitates epileptic seizures, and vice versa. However, there has been little agreement as to the brain monoamines (dopamine, norepinephrine and serotonin) most intimately involved in the seizure susceptibility.
KeywordsEpileptic Seizure Spike Activity Catecholamine Level Spike Count Epileptic Focus
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- Billiet, M., Bernard, P., Delaunois, A., De Schaepdryver, A. (1970), Induced changes in caudate nucleus dopamine and electroshock threshold. Arch. int. Pharmacodyn. 188, 396–400.Google Scholar
- De Schaepdryver, A. F., Piette, Y., Delaunois, A. L. (1962), Brain amines and electroshock threshold. Arch. int. Pharmacodyn. 140, 358–368.Google Scholar
- Laguzzi, R. F., Acevedo, C., Izquierdo, J. A. (1970), Seizure activity and hippocampal norepinephrine content. Arzneimittel-Forsch. 20, 1904–1905.Google Scholar