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Catecholamine Levels in Penicillin-Induced Epileptic Focus of the Cat Cerebral Cortex

  • K. Kobayashi
  • T. Shirakabe
  • H. Kishikawa
  • A. Mori
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 23)

Abstract

Chen et al. (1954) first reported that pretreatment with reserpine lowered the threshold of experimental seizures. Since then the relationship between brain monoamines and susceptibility to epileptic seizures has been studied by many investigators by means of electroconvulsion (De Schaepdryver et al. 1962, Azzaro et al. 1972, Kilian and Frey 1973), pentylenetetrazol (Kobinger 1958, Lessin and Parkes 1959) and audiogenic seizures (Lehmann 1967, Boggan and Seiden 1971, Jobe et al. 1973). From the results of this work, it has been suggested that treatment lowering the total brain levels of monoamines generally facilitates epileptic seizures, and vice versa. However, there has been little agreement as to the brain monoamines (dopamine, norepinephrine and serotonin) most intimately involved in the seizure susceptibility.

Keywords

Epileptic Seizure Spike Activity Catecholamine Level Spike Count Epileptic Focus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • K. Kobayashi
    • 1
  • T. Shirakabe
    • 1
  • H. Kishikawa
    • 1
  • A. Mori
    • 1
  1. 1.Institute for NeurobiologyOkayama University Medical SchoolOkayamaJapan

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