Structural Constraints in the Binding of Drugs to DNA

  • Michael Waring
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)


Drugs which interact with DNA so as to impair its function as a template for nucleic acid synthesis are used in the chemotherapy of so wide a range of infectious and malignant diseases that it is hard to over-estimate their importance in present-day medical practice. In the treatment of such conditions as malaria, trypanosomiasis, schistosomiasis and various forms of cancer they occupy a central place, in some instances providing virtually the only means of effective chemotherapy. Even among the great number of compounds which are currently under active investigation as potentially useful antiviral agents there are many whose action derives from their ability to react with nucleic acids. Small wonder, then, that this topic has been the subject of numerous reviews in recent years (see, for example, Newton, 1970; Goldberg & Friedman, 1971; Waring, 1972; Corcoran & Hahn, 1974).


Sedimentation Coefficient Nucleic Acid Synthesis Intercalate Agent Circular Molecule Trypanocidal Action 
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  • Michael Waring

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