Abstract
The long disputes over the ecological significance of R factor activity have in the course of time resolved themselves by the significance declaring itself. The protagonists in the debate could be broadly assigned to two camps: those who had believed from the earliest days of the studies of transferable drug resistance that the appearance of R factors in pathogens was a direct indication of their importance to clinicians, and those who believed that the phenomenon, though of great theoretical interest, was relatively unimportant in the ecology of the enterobacteria and related species.
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Anderson, E.S. (1975). The Ecological Significance of R Factor Activity. In: Drews, J., Hahn, E. (eds) Drug Receptor Interactions in Antimicrobial Chemotherapy. Topics in Infectious Diseases, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8405-9_5
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DOI: https://doi.org/10.1007/978-3-7091-8405-9_5
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