Physicochemical Factors in Drug-Receptor Interactions Demonstrated on the Example of the Sulfanilamides
At the beginning of my lecture I would like to make the following statement: The relation between physicochemical parameters in a homologous series of biologically active compounds and the exerted biological response can quantitatively be described by suitable mathematical and statistical treatment of the data. I hope that during my lecture I can convince you that this statement holds. It seems obvious that we can expect very close relations between the chemicals used as a drug and the biological system which acts as a receptor. Both consist of molecules. The interactions between the chemical substance and the biological systems are responsible for the effect in the organism. The reactions of enzymes or receptor systems obey the law of mass action, even if we do not yet fully understand how. If we can explore the type of interaction between the drug molecule and the receptor molecules of the target cells then we can understand the mechanism of action on a molecular level.
KeywordsMinimal Inhibition Concentration Physicochemical Parameter Sulfanilic Acid Single Point Method Folate Synthesis
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