Molecular Mechanism of Action of Rifamycins

  • Guido R. Hartmann
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)


The discussion of the molecular mechanism of action of a drug always involves three central questions: (i) what is the nature of the receptor of the drug; (ii) what is the action of the receptor bound drug; (iii) what is the structural basis of the specificity of action? In this paper more recent findings on the molecular mechanism of action of rifamycins in relation to the three central questions will be discussed. Previous results have been summarized by Wehrli & Staehelin (1971).


Large Subunit Rifampicin Resistance Molecular Receptor Temperature Dependent Equilibrium Nucleic Acid Polymerase 
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© Springer-Verlag/Wien 1975

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  • Guido R. Hartmann

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