Molecular Mechanism of Action of Rifamycins
The discussion of the molecular mechanism of action of a drug always involves three central questions: (i) what is the nature of the receptor of the drug; (ii) what is the action of the receptor bound drug; (iii) what is the structural basis of the specificity of action? In this paper more recent findings on the molecular mechanism of action of rifamycins in relation to the three central questions will be discussed. Previous results have been summarized by Wehrli & Staehelin (1971).
KeywordsLarge Subunit Rifampicin Resistance Molecular Receptor Temperature Dependent Equilibrium Nucleic Acid Polymerase
Unable to display preview. Download preview PDF.
- CALVIN, M., U.R. JOSS, A.J. HACKETT and R. OWEN: Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus. Proc. Natl. Acad. Sci. USA 68, 1441–1443 (1971).Google Scholar
- LANCINI, G., R. CRICCHIO and L. THIRY: Antiviral activity of rifamy- cins and N-aminopiperazines. J. Antibiotics 24, 64–66 (1971).Google Scholar
- MANGEL, W.F. and M.J. CHAMBERLIN: Studies of RNA chain initiation by Escherichia coli RNA polymerase bound to T7 deoxyribonucleic acid. III. The effect of temperature on ribonucleic acid chain initiation and on the conformation of binary complexes. J. Biol. Chem. 249, 3007–3013 (1974).PubMedGoogle Scholar
- MOSS, B. and E.N. ROSENBLUM: Protein cleavage and poxvirus morpho-genesis: Tryptic peptide analysis of core precursors accumulated by blocking assembly with rifampicin. J. Biol. 81, 267–269 (1973).Google Scholar