Enzyme Inhibitors as Antimicrobial Agents
The majority of our useful chemotherapeutic agents are not the product of deliberate and rational design. Most new antimicrobial agents discovered during the last 30 years have been isolated from the growth medium of filamentous fungi and Actinomycetes. The search for new compounds has been largely empirical with the main effort directed toward further exploitation of the unique synthetic abilities of the organisms in the Penicillium and Streptomyces group. A major advance in the rational design of antimicrobials was made in 1959 when it was discovered that the growth medium of Penicillium could be manipulated so that the organism produced 6-aminopenicillanic acid rather than the entire penicillin molecule (Batchelor et al. 1959). This opportunity for partial synthesis of novel penicillins was exploited skillfully by pharmaceutical chemists and compounds appeared with a variety of useful new properties (acid stability, ß-lactamase resistance).
KeywordsAntimicrobial Agent Enzyme Inhibitor Sodium Lauryl Sulfate Dihydrofolate Reductase Enzyme Binding
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