A Structural Model of the Chloramphenicol Receptor Site

  • Fred E. Hahn
  • Peter Gund
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)


Having a relatively simple chemical structure, chloramphenicol became the first antibiotic to be synthesized by organic-chemical methods (Controulis, Rebstock and Crooks, 1949). A large number of chloramphenicol derivatives was subsequently prepared. Kolosov, Shemiakin, Khokhlov and Gurevich tabulated, in 1961, more than 500 such compounds, and the total number of known chloramphenicol derivatives is, by now, much greater.


Acyl Substituent Peptidyl Transferase Bacterial Growth Inhibition Acyl Side Chain Aromatic Ring System 
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© Springer-Verlag/Wien 1975

Authors and Affiliations

  • Fred E. Hahn
  • Peter Gund

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